产品描述: | CMPDA is a positive allosteric modulator of AMPA receptors (EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor). |
靶点: |
GluR |
体外研究: |
CMPDA was nearly equipotent at modulating the two isoforms of GluA2 receptors, whereas CMPDB displayed a modest preference for the flip splice variant. CMPDA slowed the rate of deactivation of GluA2o receptors approximately 2-fold but had no effect on GluA2i receptor deactivation. |
参考文献: |
1. Timm DE, et al. Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol Pharmacol. 2011 Aug;80(2):267-80. |
溶解性: |
Soluble in DMSO |
保存条件: |
-20℃ |
配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
1 mM |
2.656 ml |
13.279 ml |
26.558 ml |
5 mM |
0.531 ml |
2.656 ml |
5.312 ml |
10 mM |
0.266 ml |
1.328 ml |
2.656 ml |
50 mM |
0.053 ml |
0.266 ml |
0.531 ml |
|
注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |