产品描述: Canthaxanthin is a red-orange carotenoid with various biological activities, such as antioxidant, antitumor properties. |
靶点:
Human Endogenous Metabolite;ReactiveOxygenSpecies |
体内研究:
Canthaxanthin alters the protective ability of tissues against oxidative stress. Canthaxanthin treatment for 15 d at the dose of 14 μg/kg body weight results in hepatic incorporation of the carotenoid, which is maximum in liver and reaches 0.52 ± 0.05 nmol/g liver. Glutathione peroxidase activity is 35% lower and catalase (59%) and manganese superoxide dismutase (28%) activities are higher in canthaxanthin-treated mice than in controls. Canthaxanthin inhibit the growth of mammary tumors in mice and the anti-tumor activity is also influenced by the supplemental dose. Diet supplementation with canthaxanthin for 3 weeks prior to the carcinogen results in a 65% reduction in the number of mammary cancers by a mechanism not involving pro-vitamin A activity |
参考文献:
1. Esatbeyoglu T, et al. Canthaxanthin: From molecule to function. Mol Nutr Food Res. 2017 Jun;61(6). 2. Huang DS, et al. Inhibitory effects of canthaxanthin on in vitro growth of murine tumor cells. Cancer Lett. 1992 Aug 31;65(3):209-13. 3. Palozza P, et al. Canthaxanthin supplementation alters antioxidant enzymes and iron concentration in liver of Balb/c mice. J Nutr. 2000 May;130(5):1303-8. 4. Chew BP, et al. A comparison of the anticancer activities of dietary beta-carotene, canthaxanthin and astaxanthin in mice in vivo. Anticancer Res. 1999 May-Jun;19(3A):1849-53. 5. Grubbs CJ, et al. Effect of canthaxanthin on chemically induced mammary carcinogenesis. Oncology. 1991;48(3):239-45. |
保存条件:
-20℃,避光,氮气保存 |
配置溶液浓度参考:
|
1mg |
5mg |
10mg |
1 mM |
1.77 ml |
8.852 ml |
17.704 ml |
5 mM |
0.354 ml |
1.77 ml |
3.541 ml |
10 mM |
0.177 ml |
0.885 ml |
1.77 ml |
50 mM |
0.035 ml |
0.177 ml |
0.354 ml |
|
注意: |
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