|
产品描述： NKL 22 (compound 4b) is a potent and selective inhibitor of histone deacetylases (HDAC), with an IC50 of 199 and 69 nM for HDAC1 and HDAC3, respectively. NKL 22 exhibits selectivity over HDAC2/4/5/7/8 (IC50≥1.59 μM). NKL 22 ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice |
|
靶点：
HDAC1：0.199 μM (IC50)；HDAC2：1.59 μM (IC50)；HDAC3：0.069 μM (IC50)；HDAC8：5 μM (IC50);HDAC |
参考文献：
1. Jia H, et, al. Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease. Neurobiol Dis. 2012 May;46(2):351-61. 2. D Herman et al. Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. Nat Chem Biol, 2006 Oct, 2(10):551-8. 3. Thomas EA, et, al. The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15564-9. |
|
溶解性：
Soluble in DMSO |
|
保存条件：
2-8℃ |
配置溶液浓度参考：
|
1mg |
5mg |
10mg |
| 1 mM |
3.073 ml |
15.366 ml |
30.731 ml |
| 5 mM |
0.615 ml |
3.073 ml |
6.146 ml |
| 10 mM |
0.307 ml |
1.537 ml |
3.073 ml |
| 50 mM |
0.061 ml |
0.307 ml |
0.615 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
北京