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• 产品描述： UF010是I类HDAC选择性抑制剂，对HDAC1、HDAC2、HDAC3、HDAC8、HDAC6和HDAC10的IC50值分别为0.5 nM、0.1 nM、0.06 nM、1.5 nM、9.1 nM和15.3 nM

• 靶点： HDAC3(Cell-free assay):0.06 nM; HDAC2(Cell-free assay):0.1 nM; HDAC1(Cell-free assay):0.5 nM; HDAC8(Cell-free assay):1.5 nM; HDAC6(Cell-free assay):9.1 nM; HDAC10:15.3 nM;HDAC

• 体外研究：
  In Cell-cycle analysis using MDA-MB-231 cells, UF010 mainly blocks G1/S transition with an increased G1 cell population and a reduced cell population in the S phase in a dose-dependent manner. UF010 has a half-life of 15.8 hr in cell culture medium containing 10% fetal bovine serum

• 细胞实验： Cell lines: HCT116 cells and A549 cells Concentrations: 2 μM Incubation Time: 1 h Method: HCT116 and A549 cells are exposed to DMSO or etoposide (Etop, 10 μM) for 6 hr. TSA (0.2 μM), MS-275, and UF010 (2 μM) are added 1 hr before cell lysis. The total cell lysates are subject to western blotting with antibodies to the indicated proteins. PCNA is detected as a loading control.

• 参考文献：
  1. Wang Y, et al. Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. Chem Biol. 2015, 22(2):273-84.

• 溶解性： Soluble  in  DMSO、Ethanol

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.688 ml	18.44 ml	36.879 ml
  5 mM	0.738 ml	3.688 ml	7.376 ml
  10 mM	0.369 ml	1.844 ml	3.688 ml
  50 mM	0.074 ml	0.369 ml	0.738 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *