货号	规格	价格	上海	北京	武汉	南京
S87676-5mg	98%	￥100.00 S87676-5mg ￥100.00 现货	10 10	-	-	-
S87676-25mg	98%	￥220.00 S87676-25mg ￥220.00 现货	8 8	-	-	-
S87676-50mg	98%	￥400.00 S87676-50mg ￥400.00 现货	5 5	-	-	-

产品介绍

RAMB4 is a ubiquitin-proteasome system (UPS)-stressor. RAMB4 inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites. RAMB4 triggers a ubiquitin-proteasome-system (UPS)-stress response without affecting 20S proteasome catalytic activities. Anticancer activity

产品描述：

靶点：

Proteasome

体外研究：

RAMB4 (0-30 µM; 48 hours) treatment produces a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively. RAMB4 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 µM. Cell Viability Assay[1] Cell Line: Keratinocytes, SiHa, CaSki and ME180 cells Concentration: 5, 10, 15, 20, 25, 30 µM Incubation Time: 48 hours Result: Produced a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively with minimal effects on the viability of primary human keratinocytes and with IC50 similar to the obtained with HeLa cells.

参考文献：

1. Anchoori RK, et al. Stressing the ubiquitin-proteasome system without 20S proteolytic inhibition selectively kills cervical cancer cells.PLoS One. 2011;6(8):e23888.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.421 ml	12.103 ml	24.206 ml
5 mM	0.484 ml	2.421 ml	4.841 ml
10 mM	0.242 ml	1.21 ml	2.421 ml
50 mM	0.048 ml	0.242 ml	0.484 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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PTP1B-IN-9