PTP1B-IN-9 98%

PTP1B-IN-9

源叶(MedMol)
S87676
145888-79-5
C19H13Cl4NO
413.12
(3E,5E)-3,5-Bis(3,4-dichlorobenzylidene)piperidin-4-one
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S87676-5mg 98% ¥100.00元 10 - - -
源叶(MedMol) S87676-25mg 98% ¥220.00元 8 - - -
源叶(MedMol) S87676-50mg 98% ¥400.00元 5 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

RAMB4 is a ubiquitin-proteasome system (UPS)-stressor. RAMB4 inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites. RAMB4 triggers a ubiquitin-proteasome-system (UPS)-stress response without affecting 20S proteasome catalytic activities. Anticancer activity
产品描述: RAMB4 is a ubiquitin-proteasome system (UPS)-stressor. RAMB4 inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites. RAMB4 triggers a ubiquitin-proteasome-system (UPS)-stress response without affecting 20S proteasome catalytic activities. Anticancer activity
靶点: Proteasome
体外研究: RAMB4 (0-30 µM; 48 hours) treatment produces a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively. RAMB4 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 µM. Cell Viability Assay[1] Cell Line: Keratinocytes, SiHa, CaSki and ME180 cells Concentration: 5, 10, 15, 20, 25, 30 µM Incubation Time: 48 hours Result: Produced a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively with minimal effects on the viability of primary human keratinocytes and with IC50 similar to the obtained with HeLa cells.
参考文献: 1. Anchoori RK, et al. Stressing the ubiquitin-proteasome system without 20S proteolytic inhibition selectively kills cervical cancer cells.PLoS One. 2011;6(8):e23888.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.421 ml 12.103 ml 24.206 ml
5 mM 0.484 ml 2.421 ml 4.841 ml
10 mM 0.242 ml 1.21 ml 2.421 ml
50 mM 0.048 ml 0.242 ml 0.484 ml
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参考文献

质检证书(COA)

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摩尔浓度计算器

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