UV0155041 98%

(±)-cis-2-(3,5-Dichlorophenylcarbamoy)cyclohexanecarboxylic Acid

源叶(MedMol)
S87785
1093757-42-6
C14H15Cl2NO3
316.18
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S87785-1mg 98% ¥190.00元 10 - - -
源叶(MedMol) S87785-5mg 98% ¥220.00元 6 - - -
源叶(MedMol) S87785-10mg 98% ¥310.00元 6 - - -
源叶(MedMol) S87785-25mg 98% ¥410.00元 6 - - -
源叶(MedMol) S87785-50mg 98% ¥550.00元 预计交期:2-3天 - - -
源叶(MedMol) S87785-100mg 98% ¥740.00元 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

VU0155041 is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD)
产品描述: VU0155041 is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD)
靶点: Human mGlu4:798 nM (EC50);Rat mGlu4:693 nM (EC50);GluR
体内研究: VU0155041 (31 nmol, 93 nmol; i.c.v.) reverses catalepsy induced by the dopamine D2 receptor antagonist Haloperidol (1.5 mg/kg, i.p.) in rats[1].VU0155041 (93 nnmol, 316 nmol; i.c.v.) reverses Reserpine (HY-N0480)-induced akinesia in rats. Animal Model: Third ventricle cannulated (TVC) Male Sprague-Dawley rats (225-255 g) Dosage: 31 nmol, 93 nmol (10 μL) Administration: Intracerebroventrical injection, after the Haloperidol (1.5 mg/kg) treatment 2 hours Result: Decreased the cataleptic effects of Haloperidol, and the effects still presented 30 min after infusion.
参考文献: 1. Niswender CM, et, al. Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol Pharmacol. 2008 Nov; 74(5): 1345-58.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 3.163 ml 15.814 ml 31.628 ml
5 mM 0.633 ml 3.163 ml 6.326 ml
10 mM 0.316 ml 1.581 ml 3.163 ml
50 mM 0.063 ml 0.316 ml 0.633 ml
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参考文献

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