• 产品描述： MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD)

• 靶点： PPARδ:0.4 nM (EC50, in human);PPARδ:7.9 nM (EC50, in mouse);PPARδ:10 nM (EC50, in rat);PPAR

• 体外研究：
  MA-0204 is >10,000-fold selective for activation of PPARδ over PPARα and PPARγ receptors. MA-0204 exhibits high protein binding to mouse plasma, good permeability and low potential for efflux. C. MA-0204 (1.2-12 nM) improves fatty acid oxidation in DMD patient muscle myoblasts mice. MA-0204 (0.04-40 nM) engages target gene expression in DMD patient muscle myoblasts

• 体内研究：
  PPARδ (30, 100 mg/kg) increases target gene transcription in the muscle

• 参考文献：
  1. Lagu B, et al. Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD). ACS Med Chem Lett. 2018 Jul 31;9(9):935-940.

• 溶解性： Soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.099 ml	10.493 ml	20.987 ml
  5 mM	0.42 ml	2.099 ml	4.197 ml
  10 mM	0.21 ml	1.049 ml	2.099 ml
  50 mM	0.042 ml	0.21 ml	0.42 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *