| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
| S88201-1mg | 98% | ￥500.00 | 4 | - | - | - |
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| S88201-5mg | 98% | ￥1200.00 | 6 | - | - | - |
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| S88201-10mg | 98% | ￥2200.00 | 6 | - | - | - |
|
| S88201-25mg | 98% | ￥4000.00 | 4 | - | - | - |
|
| S88201-100mg | 98% | ￥10000.00 | 货期：2-3天 | - | - | - |
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Furan fatty acids are unique, naturally occurring lipids that are found in significant amounts in dietary phospholipids, such as in salmon roe.CMPF is an endogenous metabolite of furan fatty acids in humans. CMPF is highly albumin-bound and accumulates in the serum of uremic patients to concentrations in excess of 0.2 mM. Its primary effect is to inhibit cellular transport and subsequent deiodination of thyroxine (T4).CMPF is tightly bound to albumin but only moderately inhibits T4 binding in a direct manner (10-14% at 0.3 mM). However, CMPF effectively displaces competitive T4 binding molecules from albumin, such as acidic drugs and free fatty acids.Therefore, CMPF may indirectly influence T4 binding to albumin by increasing the serum concentration of competitive binding molecules, particularly free fatty acids such as oleic acid.
| 产品描述： | Furan fatty acids are unique, naturally occurring lipids that are found in significant amounts in dietary phospholipids, such as in salmon roe.CMPF is an endogenous metabolite of furan fatty acids in humans. CMPF is highly albumin-bound and accumulates in the serum of uremic patients to concentrations in excess of 0.2 mM. Its primary effect is to inhibit cellular transport and subsequent deiodination of thyroxine (T4).CMPF is tightly bound to albumin but only moderately inhibits T4 binding in a direct manner (10-14% at 0.3 mM). However, CMPF effectively displaces competitive T4 binding molecules from albumin, such as acidic drugs and free fatty acids.Therefore, CMPF may indirectly influence T4 binding to albumin by increasing the serum concentration of competitive binding molecules, particularly free fatty acids such as oleic acid. | ||||||||||||||||||||
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| 靶点： | MicrotubuleAssociated | ||||||||||||||||||||
| 参考文献： | 1. Ishii, K., Okajima, H., Okada, Y., et al. Studies on furan fatty acids of salmon roe phospholipids. Journal of Biochemistry 103(5), 836-839 (1988). 2. Lim, C.F., Bernard, B.F., De Jong, M., et al. A furan fatty acid and indoxyl sulfate are the putative inhibitors of thyroxine hepatocyte transport in uremia. Journal of Clinical Endocrinology and Metabolism 76(2), 318-324 (1993). 3. Lim, C.F., Stockigt, J.R., Curtis, A.J., et al. A naturally occuring furan fatty acid enhances drug inhibition of thyroxine binding in serum. Metabolism 42(11), 1468-1474 (1993). | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、Ethanol、DMF | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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