JNJ0966 98%

JNJ0966

源叶(MedMol)
S88647
315705-75-0
C16H16N4O2S2
360.45
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S88647-1mg 98% ¥140.00元 3 - - -
源叶(MedMol) S88647-5mg 98% ¥330.00元 4 - - -
源叶(MedMol) S88647-10mg 98% ¥440.00元 5 - - -
源叶(MedMol) S88647-25mg 98% ¥590.00元 4 - - -
源叶(MedMol) S88647-50mg 98% ¥790.00元 预计交期:2-3天 - - -
源叶(MedMol) S88647-100mg 98% ¥1350.00元 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM
产品描述: JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM
靶点: IC50: 440 nM (MMP-9 zymogen);MMP
体外研究: JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM. The activations of proMMP-1, proMMP-2, and proMMP-3 are not significantly different in the presence or absence of 10 μM JNJ0966, whereas proMMP-9 activation by trypsin is significantly attenuated by JNJ0966. The addition of JNJ0966 to the reaction results in a significant reduction in fully processed MMP-9 and an apparent accumulation of the intermediate species
体内研究: The exposures of JNJ0966 are dose-dependent, with plasma and brain concentrations for the 10-mg/kg dose of 77.5±31.1 ng/mL (215 nM) and 481.6±162.5 ng/g (~1336 nM), respectively, whereas the 30-mg/kg dose achieves 293.6±118.4 ng/mL (815 nM) in plasma and 1394.0±649.1 ng/g (~3867 nM) in brain. JNJ0966 is preferentially partitioned in brain, with brain/plasma ratios of 6.2 for the 10-mg/kg dose and 4.7 for the 30-mg/kg dose
参考文献: 1. Scannevin RH, et al. Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) thatallosterically inhibits zymogen activation. J Biol Chem. 2017 Oct 27;292(43):17963-17974.
溶解性: Soluble  in  DMSO
保存条件: -20°C
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.774 ml 13.872 ml 27.743 ml
5 mM 0.555 ml 2.774 ml 5.549 ml
10 mM 0.277 ml 1.387 ml 2.774 ml
50 mM 0.055 ml 0.277 ml 0.555 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

如何获取质检证书(COA)?
请输入货号和一个与之匹配的批号。
例如:
批号:JS298415 货号:S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

=
×
×

相关产品