| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S88761-2mg |
99.9% | ￥382.50 | 5 | - | - | - |
|
S88761-5mg |
99.9% | ￥595.00 | 6 | - | - | - |
|
S88761-10mg |
99.9% | ￥935.00 | 8 | - | - | - |
|
S88761-25mg |
99.9% | ￥1480.00 | 6 | - | - | - |
|
S88761-50mg |
≥98% | ￥2350.00 | 货期：2-3天 | - | - | - |
|
S88761-100mg |
≥98% | ￥4200.00 | 货期：2-3天 | - | - | - |
|
NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM.
| 产品描述： | NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM. | ||||||||||||||||||||
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| 靶点： | IC50: 1 μM (PI5P4Kγ);PI3K | ||||||||||||||||||||
| 体外研究： | NIH-12848 inhibits PI5P4Kγ with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. NIH-12848 inhibits the translocation of Na+/ K+-ATPase to the plasma membrane that occurs when mpkCCD cells grow to confluence and also prevents reversibly their forming of ‘domes’ on the culture dish. Both these NIH-12848-induced effects are mimicked by specific RNAi knockdown of PI5P4Kγ, but not that of PI5P4Ks α or β. NIH-12848 could be a potentially powerful tool for exploring the cell physiology of PI5P4Ks | ||||||||||||||||||||
| 参考文献： | 1. Clarke JH, et al. The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site. Biochem J. 2015 Mar 1;466(2):359-67. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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