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产品描述： NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM. |
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靶点：
IC50: 1 μM (PI5P4Kγ);PI3K |
体外研究：
NIH-12848 inhibits PI5P4Kγ with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. NIH-12848 inhibits the translocation of Na+/ K+-ATPase to the plasma membrane that occurs when mpkCCD cells grow to confluence and also prevents reversibly their forming of ‘domes’ on the culture dish. Both these NIH-12848-induced effects are mimicked by specific RNAi knockdown of PI5P4Kγ, but not that of PI5P4Ks α or β. NIH-12848 could be a potentially powerful tool for exploring the cell physiology of PI5P4Ks |
参考文献：
1. Clarke JH, et al. The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site. Biochem J. 2015 Mar 1;466(2):359-67. |
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溶解性：
Soluble in DMSO |
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保存条件：
-20°C |
配置溶液浓度参考：
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1mg |
5mg |
10mg |
| 1 mM |
2.595 ml |
12.973 ml |
25.946 ml |
| 5 mM |
0.519 ml |
2.595 ml |
5.189 ml |
| 10 mM |
0.259 ml |
1.297 ml |
2.595 ml |
| 50 mM |
0.052 ml |
0.259 ml |
0.519 ml |
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| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京