S88774 |
HCH6-1 |
源叶(MedMol) | 98% |
- 产品描述: HCH6-1 is a potent and competitive dipeptide antagonist of Formyl peptide receptor 1 (FPR1). HCH6-1 inhibits chemotaxis, superoxide anion generation, and elastase release in human neutrophils specifically activated by fMLF (an FPR1 agonist). HCH6-1 has protective effects against acute lung injury (ALI) in vivo and can be used for the research of FPR1-involved inflammatory lung diseases
- 靶点: IC50: Formyl peptide receptor 1 (FPR1)
- 体内研究:
HCH6-1 (intraperitoneal injection; 50 mg/kg; 1 h before LPS spray or 30 min after LPS spray) alone does not induce airspace inflammation. HCH6-1 pretreatment reduces inflammatory cell infiltration and distortion of pulmonary architecture in the presence of LPS. HCH6-1 posttreatment shows inhibitory effects on neutrophil accumulation and lung damage in LPS-induced ALI mice Animal Model: C57BL/6 mice (20-25 g, 7-8 weeks old) Dosage: 50 mg/kg Administration: Intraperitoneal injection; 50 mg/kg; 1 h before LPS spray or 30 min after LPS spray Result: Ameliorated ALI in LPS-induced mice.HCH6-1-mediated decreasing of neutrophil recruitment serves as a protective mechanism in ALI mice.
- 参考文献:
1. Yang SC, et al. Dipeptide HCH6-1 inhibits neutrophil activation and protects against acute lung injury by blocking FPR1. Free Radic Biol Med. 2017 May;106:254-269
- 溶解性: Soluble in DMSO
- 保存条件: -20℃
- 配置溶液浓度参考:
1mg 5mg 10mg 1 mM 2.13 ml 10.649 ml 21.298 ml 5 mM 0.426 ml 2.13 ml 4.26 ml 10 mM 0.213 ml 1.065 ml 2.13 ml 50 mM 0.043 ml 0.213 ml 0.426 ml
- 注意:部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。
输入产品批号:
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)