• 产品描述： Elimusertib (BAY-1895344) is a very potent and highly selective ATR (ataxia telangiectasia and Rad3-related) inhibitor with IC50 of 7 nM. Elimusertib potently inhibits proliferation of a broad spectrum of human tumor cell lines with median IC50 of 78 nM.

• 靶点： ATR(Cell-free assay):7 nM;ATM/ATR

• 体外研究：
  BAY-1895344 inhibits tumor cell growth and viability and exhibits potent antiproliferative activity in a broad spectrum of human tumor cell lines

• 体内研究：
  BAY 1895344 exhibits strong monotherapy efficacy in cancer xenograft models that carry DNA damage repair deficiencies.

• 细胞实验： Cell lines: HT-29 cells, M059J cells, 38 cancer cell lines Concentrations: 3–300 nM Incubation Time: 72 to 96 hours Method: The antiproliferative activity of BAY 1895344 is evaluated against a panel of 38 cancer cell lines. Cell proliferation is measured after 72 to 96 hours of exposure to BAY1895344. Cell viability is determined using crystal violet staining or the CellTiter-Glo Cell Viability Assay.

• 动物实验： Animal Models: female SCID beige mice, female C.B-17 SCID mice, male NMRI nude mice, female NMRI nude mice Dosages: 50 mg/kg Administration: Oral gavage

• 参考文献：
  1. Ulrich T. Luecking, et al. Cancer Res 2017;77(13 Suppl):Abstract nr 983. 2. Antje M Wengner, et al. Mol Cancer Ther. 2020 Jan;19(1):26-38.

• 溶解性： Soluble  in  DMSO、Ethanol

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.428 ml	12.139 ml	24.278 ml
  5 mM	0.486 ml	2.428 ml	4.856 ml
  10 mM	0.243 ml	1.214 ml	2.428 ml
  50 mM	0.049 ml	0.243 ml	0.486 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *