品牌	货号	产品规格	价格(RMB)	库存（上海）	北京	武汉	南京
源叶(MedMol)	S89975-2mg	98%	￥400.00元	10	-	-	-
源叶(MedMol)	S89975-5mg	98%	￥800.00元	2	-	-	-
源叶(MedMol)	S89975-25mg	98%	￥2400.00元	2	-	-	-
源叶(MedMol)	S89975-100mg	98%	￥5600.00元	预计交期：2-3天	-	-	-

品牌

货号

产品规格

价格(RMB)

库存（上海）

北京

武汉

南京

购买数量

源叶(MedMol)

S89975-2mg

98%

￥400.00元

源叶(MedMol)

S89975-5mg

98%

￥800.00元

源叶(MedMol)

S89975-25mg

98%

￥2400.00元

源叶(MedMol)

S89975-100mg

98%

￥5600.00元

预计交期：2-3天

产品介绍

Elimusertib (BAY-1895344) is a very potent and highly selective ATR (ataxia telangiectasia and Rad3-related) inhibitor with IC50 of 7 nM. Elimusertib potently inhibits proliferation of a broad spectrum of human tumor cell lines with median IC50 of 78 nM.

产品描述： Elimusertib (BAY-1895344) is a very potent and highly selective ATR (ataxia telangiectasia and Rad3-related) inhibitor with IC50 of 7 nM. Elimusertib potently inhibits proliferation of a broad spectrum of human tumor cell lines with median IC50 of 78 nM.

靶点： ATR(Cell-free assay):7 nM;ATM/ATR

体外研究：
BAY-1895344 inhibits tumor cell growth and viability and exhibits potent antiproliferative activity in a broad spectrum of human tumor cell lines

体内研究：
BAY 1895344 exhibits strong monotherapy efficacy in cancer xenograft models that carry DNA damage repair deficiencies.

细胞实验： Cell lines: HT-29 cells, M059J cells, 38 cancer cell lines Concentrations: 3–300 nM Incubation Time: 72 to 96 hours Method: The antiproliferative activity of BAY 1895344 is evaluated against a panel of 38 cancer cell lines. Cell proliferation is measured after 72 to 96 hours of exposure to BAY1895344. Cell viability is determined using crystal violet staining or the CellTiter-Glo Cell Viability Assay.

动物实验： Animal Models: female SCID beige mice, female C.B-17 SCID mice, male NMRI nude mice, female NMRI nude mice Dosages: 50 mg/kg Administration: Oral gavage

参考文献：
1. Ulrich T. Luecking, et al. Cancer Res 2017;77(13 Suppl):Abstract nr 983. 2. Antje M Wengner, et al. Mol Cancer Ther. 2020 Jan;19(1):26-38.

溶解性： Soluble in DMSO、Ethanol

保存条件： -20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.428 ml	12.139 ml	24.278 ml
5 mM	0.486 ml	2.428 ml	4.856 ml
10 mM	0.243 ml	1.214 ml	2.428 ml
50 mM	0.049 ml	0.243 ml	0.486 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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Elimusertib hydrochloride 98%

BAY-1895344 hydrochloride

产品介绍

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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