| 产品描述： | XAV-939 is a Tankyrase inhibitor. XAV-939 has inhibitory activity for TNKS1 and TNKS2 with IC50 values of 5 nM and 2 nM, respectively. XAV-939 also is an enhancer of osteoblastic differentiation of hMSCs. XAV-939 can be used for the research of conditions associated with activated Wnt signaling, such as cancer, fibrotic diseases and conditions associated with low bone formation |
| 靶点： |
TNKS2:2 nM (IC50);TNKS1:5 nM (IC50);ARTD2:479 nM (IC50)；ARTD1：5500 nM (IC50);PARP;Wnt/beta-catenin |
| 体内研究： |
XAV-939 rescues mechanical stress-induced cartilage degeneration in vivo |
| 参考文献： |
1. Mohit Narwal, et al. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 2013 Oct 24;56(20):7880-9. 2. Nuha Almasoud, et al. Tankyrase inhibitor XAV-939 enhances osteoblastogenesis and mineralization of human skeletal (mesenchymal) stem cells. Sci Rep. 2020 Oct 7;10(1):16746. 3. Senxin Cai, et al. Mechanical stress reduces secreted frizzled-related protein expression and promotes temporomandibular joint osteoarthritis via Wnt/β-catenin signaling. Bone. 2022 Aug;161:116445. |
| 溶解性： |
DMSO : 15.62 mg/mL (50.01 mM; ultrasonic and warming and heat to 60°C) H2O : < 0.1 mg/mL (insoluble) |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.202 ml |
16.01 ml |
32.019 ml |
| 5 mM |
0.64 ml |
3.202 ml |
6.404 ml |
| 10 mM |
0.32 ml |
1.601 ml |
3.202 ml |
| 50 mM |
0.064 ml |
0.32 ml |
0.64 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京