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• 产品描述： PHTPP is a selective ERβ antagonist.

• 靶点： Estrogen Receptor/ERR;Estrogen/progestogen Receptor;EstrogenReceptor/ERR;Estrogen/progestogenReceptor

• 细胞实验： Cells are plated at a density of 3 to 4×10^5 in 1 mL of medium per well in a 24-well plate for cell viability and cAMP analysis. Cells are cultured in Dulbecco's Modified Eagle Medium with PHTPP (1 μM), or ethanol (0.1%) as the vehicle. The incubator is set to an atmosphere of 5% CO2 in air at 37°C, and cultures are allowed to acclimate for at least 24 h. The culture medium is then aspirated and replaced with serum-free DMEM/F12 containing 0.1 μM androstenedione. The cells are collected for intracellular cAMP and to test cell viability. They are for reference only.

• 参考文献：
  1.Wang K, Chen Y, Gao S, et al. Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting ERα to inhibit RANKL signaling[J]. Acta Pharmaceutica Sinica B. 2020 2.Compton DR, etal. Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity. J Med Chem. 2004 Nov 18;47(24):5872-93.

• 溶解性： Soluble  in  DMSO

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.362 ml	11.812 ml	23.623 ml
  5 mM	0.472 ml	2.362 ml	4.725 ml
  10 mM	0.236 ml	1.181 ml	2.362 ml
  50 mM	0.047 ml	0.236 ml	0.472 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

• 1. [IF=4.285] Li Pan et al."ESR1 mediates estrogen-induced feminization of genetic male Chinese soft-shelled turtle."BIOLOGY OF REPRODUCTION. 2022 May;:

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *