208. [IF=1.3] Jia-Le Ren et al."Unveiling the neuroprotective mystery of Kaixinsan: identifying and validating the neuroprotective ingredients under the perspective of gut – brain axis regulation."JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH. 207. [IF=2.8] Ruobing Bai et al."Total ginsenosides from wild ginseng improve immune regulation in a rat model of spleen qi deficiency by modulating fecal-bacteria-associated short-chain fatty acids and intestinal barrier integrity."JOURNAL OF CHROMATOGRAPHY B-ANALYTIC 206. [IF=4.9] Yanbing Pan et al."Simultaneous detection of tanshinone I and cryptotanshinone using a carbon fiber microelectrode based on gold–palladium composite network."MICROCHEMICAL JOURNAL.2025 Mar;:113378 205. [IF=4.8] Li He et al."Dunhuang Dabupi Decoction and its active components alleviate ulcerative colitis by activating glutathione metabolism and inhibiting JAK-STAT pathway in Drosophila and mice."JOURNAL OF ETHNOPHARMACOLOGY.2025 Apr;346:119717 204. [IF=6.8] Feiyan Chen et al."Identification of AIF1 as a protein target of notoginsenosides in brain tissue of mice with intracerebral hemorrhage based on hapten immunoaffinity fishing technique."Journal of Ginseng Research.2025 Apr;: 203. [IF=4.9] Junru Chen et al."Ginsenoside Rg1 Prevents and Treats Acute Pulmonary Injury Induced by High-Altitude Hypoxia."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2024 Nov;25(22):12051 202. [IF=4.4] Ye Qiu et al."Changes in the chemical composition and medicinal effects of black ginseng during processing."Frontiers in Pharmacology.2024 Nov;15: 201. [IF=3.1] Ze-xuan Chen et al."Metabolite profiling of Shenhua compound in rats and pharmacokinetics study of four bioactive compounds with liquid chromatography combined with electrospray ionization tandem mass spectrometry."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL 200. [IF=4.4] Chaokai Yang et al."Xixin Decoction’s novel mechanism for alleviating Alzheimer’s disease cognitive dysfunction by modulating amyloid-β transport across the blood–brain barrier to reduce neuroinflammation."Frontiers in Pharmacology.2025 Jan;15:1508726 199. [IF=3.2] Chang Wang et al."Different processing methods affect the chemical composition and in vitro anti-tumor activity of ginseng."JOURNAL OF FOOD SCIENCE.2025 Jan;90(1):e17639 198. [IF=3.9] Pengdi Yang et al."A novel strategy for the protective effect of ginsenoside Rg1 against ovarian reserve decline by the PINK1 pathway."PHARMACEUTICAL BIOLOGY. 197. [IF=6.8] Yilin Wang et al."Involvement of Piezo 1 in inhibition of shear-induced platelet activation and arterial thrombosis by ginsenoside Rb1."BRITISH JOURNAL OF PHARMACOLOGY.2025 Feb;: 196. [IF=4.8] Xu Jing et al."Ginsenoside 1 mitigates postoperative cognitive dysfunction by enhancing microglial Aβ clearance through the endo-lysosomal pathway."INTERNATIONAL IMMUNOPHARMACOLOGY.2025 Mar;150:114281 195. [IF=4.8] Cuiting Yang et al."Fermentation interactions and lipid-lowering potential of Monascus purpureus fermented Ginseng."Food Bioscience.2025 Apr;66:106260 194. [IF=4.8] Yuzhen Liu et al."ShenJiaoLingCao Decoction ameliorates cyclophosphamide-induced splenic injury and immunosuppression via the inhibition of MEK/ERK signaling pathway activity and modulation of amino acid metabolism."JOURNAL OF ETHNOPHARMACOLOGY.2025 Apr;: 193. [IF=2.9] Ning Xu et al."Water extract of ginseng alleviates parkinsonism in MPTP–induced Parkinson’s disease mice."PLoS One.2024 Sep;19(9):e0296424 192. [IF=3.4] Sethuraman Sathya et al."Comparison of chemical components and quality evaluation of Panax ginseng and its processed products from different habitats in Northeastern China."Biocatalysis and Agricultural Biotechnology.2024 Oct;61:103375 191. [IF=4.3] Wu Dehua et al."Temperature seasonality and soil phosphorus availability shape ginseng quality via regulating ginsenoside contents."BMC PLANT BIOLOGY.2024 Dec;24(1):1-12 190. [IF=8.5] Jiabao Feng et al."Analysis of sediment re-formation factors after ginseng beverage clarification based on XGBoost machine learning algorithm."FOOD CHEMISTRY.2024 Sep;:141304 189. [IF=6.8] Yun Zhao et al."The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination."BRITISH JOURNAL OF PHARMACOLOGY.2024 Sep;: 188. [IF=6.9] Wang Sha-sha et al."Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle."ACTA PHARMACOLOGICA SINICA.2024 Sep;:1-18 187. [IF=3.3] Rong Liu et al."Characterization of a Xylosyltransferase from Panax notoginseng Catalyzing Ginsenoside 2′-O Glycosylation in the Biosynthesis of Notoginsenosides."JOURNAL OF NATURAL PRODUCTS.2024;XXXX(XXX):XXX-XXX 186. [IF=14.3] Xietao Ye et al."Monocyte/Macrophage-Mediated Transport of Dual-Drug ZIF Nanoplatforms Synergized with Programmed Cell Death Protein-1 Inhibitor Against Microsatellite-Stable Colorectal Cancer."Advanced Science.2024 Aug;:2405886 185. [IF=6.8] Xiaojin Xu et al."Ginsenoside Rg1 reduces cardiac inflammation against myocardial ischemia/reperfusion injury by inhibiting macrophage polarization."Journal of Ginseng Research.2024 Jul;: 184. [IF=2.8] Liang Liwen et al."Identification of Potential α-Glucosidase Inhibitors from American Ginseng Processed Products by UHPLC-Q-Orbitrap/MS and Molecular Docking."Food Biophysics.2024 Jun;:1-13 183. [IF=3.4] Yanqiu Zheng et al."WeiNaiAn capsule attenuates intestinal mucosal injury and regulates gut microbiome in indomethacin-induced rat."INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY.2024 Jun;:106609 182. [IF=5.7] Zehua Zhou et al."Ginsenoside Rg1 Suppresses Pyroptosis via the NF-κB/NLRP3/GSDMD Pathway to Alleviate Chronic Atrophic Gastritis In Vitro and In Vivo."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2024;XXXX(XXX):XXX-XXX 181. [IF=5.9] Jing Fang et al."Effects of soil microbial ecology on ginsenoside accumulation in Panax ginseng across different cultivation years."INDUSTRIAL CROPS AND PRODUCTS".2024 Sep;215:118637 180. [IF=5.4] Yunfeng Di et al."Mass Production of Rg1-Loaded Small Extracellular Vesicles Using a 3D Bioreactor System for Enhanced Cardioprotective Efficacy of Doxorubicin-Induced Cardiotoxicity."Pharmaceutics".2024 May;16(5):593 179. [IF=12.9] Bin Wei et al."Rational Design of Spontaneous Self-Cyclization Enzymes In Vivo and In Vitro with Improved Thermal Tolerance and Activity."ACS Catalysis".2024;14(7):5469–5480 178. [IF=2.7] Wenjie Su et al."Therapeutic effect of notoginseng saponins before and after fermentation on blood deficiency rats."Experimental and Therapeutic Medicine".2024 Apr;27(4):1-16 177. [IF=5] Dong-Ling Cai et al."Ginsenoside Rg1 promotes fetal hemoglobin production in vitro: A potential therapeutic avenue for β-thalassemia."EUROPEAN JOURNAL OF PHARMACOLOGY".2024 Apr;968:176404 176. [IF=5.2] Baoyu Fu et al."New insights into ginsenoside Rg1 regulating the niche to inhibit age-induced germline stem cells depletion through targeting ECR/BMP signaling pathway in Drosophila."Aging-US".2024 Feb 28; 16(4): 3612–3630 175. [IF=5.9] Yujuan Zhang et al."Physiological, biochemical and transcriptional analysis reveals the response mechanism of Panax quinquefolius to the stressors of drought and waterlogging."INDUSTRIAL CROPS AND PRODUCTS".2024 May;211:118235 174. [IF=6.3] Rongfang Xie et al."Integration of virtual screening and proteomics reveals potential targets and pathways for ginsenoside Rg1 against myocardial ischemia."Journal of Ginseng Research".2024 Feb;: 173. [IF=8.6] Minghui Li et al."Natural deep eutectic solvents-based selective extraction of saponins from Panax notoginseng: Process optimization, chemical profiling, and bioactivities evaluation."SEPARATION AND PURIFICATION TECHNOLOGY".2024 Aug;341:126882 172. [IF=5.6] Bin Xu et al."Identification of ginsenoside components from adventitious root of ginseng and their hypoglycemic effects on T1DM mice: A network pharmacology and animal experiment study."Journal of Functional Foods".2024 May;116:106083 171. [IF=1.6] Dai Tingting et al."Prediction of molecular mechanism of processed ginseng in the treatment of heart failure based on network pharmacology and molecular docking technology."MEDICINE.2023 Dec;102(49):e36576 170. [IF=8.8] Haiyang Li et al."Research on rapid quality identification method of Panax notoginseng powder based on artificial intelligence sensory technology and multi-source information fusion technology."FOOD CHEMISTRY.2024 May;440:138210 169. [IF=8.8] Shiying Luo et al."Spatial metabolomics method to reveal differential metabolomes in microregions of Panax quinquefolius roots by using ultra-performance liquid chromatography quadrupole/time of flight-mass spectrometry and desorption electrospray ionizati 168. [IF=3.1] Gan Chen et al."Metabolomics approach to growth-age discrimination in mountain-cultivated ginseng (Panax ginseng C. A. Meyer) using ultra-high-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry."JOURNAL OF SEPARATION 167. [IF=3.5] Zhu Cun et al."Integrated metabolome and transcriptome analysis reveals the regulatory mechanism of low nitrogen-driven biosynthesis of saponins and flavonoids in Panax notoginseng."GENE.2024 Jan;:148163 166. [IF=5.4] Yingqiu Shi et al."Effective constituents and protective effect of Mudan granules against Schwann cell injury."JOURNAL OF ETHNOPHARMACOLOGY.2024 Apr;323:117692 165. [IF=3.4] Jiaxin Yin et al."Comprehensive multicomponent characterization and quality assessment of Xiaoyao Wan by UPLC-Q-Orbitrap-MS, HS-SPME-GC-MS and HS-GC-IMS."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2024 Feb;239:115910 164. [IF=0.7] Xunjun Shen et al."GRg1 Ameliorates Insulin Resistance Through Activation of the PI3K/AKT/GSK-3β Pathway in HepG2 Cells."Pharmacognosy Magazine.;(): 163. [IF=2.9] Bai Yuxin et al."UHPLC–HRMS based saponins profiling of three morphological regions in American ginseng (Panax quinquefolium L.) and their correlation with the antioxidant activity."FOOD SCIENCE AND BIOTECHNOLOGY.2023 Nov;:1-12 162. [IF=4.8] Guozhuang Zhang et al."Rhizosphere effects on the microbial community: Specificity and conservatism across geographically disjunct Panax species."APPLIED SOIL ECOLOGY.2023 Dec;192:105075 161. [IF=3.1] Jiawei Zhang et al."Ginsenoside Rg1 improved learning and memory ability and reduces neuronal apoptosis in epileptic rats through ERK/CREB/BDNF signal pathway."BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2023 Jul;: 160. [IF=5.8] Shangmin Yu et al."Borneol-modified PEGylated graphene oxide as a nanocarrier for brain-targeted delivery of ginsenoside Rg1 against depression."INTERNATIONAL JOURNAL OF PHARMACEUTICS.2023 Aug;643:123284 159. [IF=8.2] Zhenning Di et al."A Gellan Gum/Sodium Alginate-based gastric-protective hydrogel loaded with a combined herbal extract consisting of Panax notoginseng, Bletilla striata and Dendrobium officinale."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2023 Oc 158. [IF=7.9] Zhang Guozhuang et al."Modules in robust but low-efficiency phyllosphere fungal networks drive saponin accumulation in leaves of different Panax species."Environmental Microbiome.2023 Dec;18(1):1-15 157. [IF=2.838] Xu Manman et al."Kaixin Jieyu Granule attenuates neuroinflammation-induced depressive-like behavior through TLR4/PI3K/AKT/FOXO1 pathway: a study of network pharmacology and experimental validation."BMC Complementary Medicine and Therapies.2023 Dec;23(1):1 156. [IF=4.546] Xu Ying et al."Panax notoginseng saponins inhibits NLRP3 inflammasome-mediated pyroptosis by downregulating lncRNA-ANRIL in cardiorenal syndrome type 4."Chinese Medicine.2023 Dec;18(1):1-13 155. [IF=3.2] Yuqing Xu et al."Optimization of Rare Ginsenosides and Antioxidant Activity Quality of Ginseng Jiaosu Based on Probiotic Strains and Fermentation Technology."JOURNAL OF FOOD QUALITY.2023;2023:5686929 154. [IF=5.735] Feiyan Chen et al."Discovery and validation of PURA as a transcription target of 20(S)-protopanaxadiol: Implications for the treatment of cognitive dysfunction."Journal of Ginseng Research.2023 Apr;: 153. [IF=6.388] He Zhang et al."Prevention effect of total ginsenosides and ginseng extract from Panax ginseng on cyclophosphamide-induced immunosuppression in mice."PHYTOTHERAPY RESEARCH.2023 Apr;: 152. [IF=1.193] Song Fengyuan et al."Preparation of solid dispersion of Dushen decoction and establishment of its evaluation method."CHINESE JOURNAL OF ANALYTICAL CHEMISTRY.2023 Mar;:100259 151. [IF=3.408] Ping Di et al."LED Light Irradiations Differentially Affect the Physiological Characteristics, Ginsenoside Content, and Expressions of Ginsenoside Biosynthetic Pathway Genes in Panax ginseng."Agriculture-Basel.2023 Apr;13(4):807 150. [IF=4.145] Yue Guan et al."Ginsenoside Rg1 attenuates cerebral ischemia-reperfusion injury through inhibiting the inflammatory activation of microglia."EXPERIMENTAL CELL RESEARCH.2023 May;426:113552 149. [IF=4.927] Junchen Liu et al."Anti-Inflammatory Activity of Panax notoginseng Flower Saponins Quantified Using LC/MS/MS."MOLECULES.2023 Jan;28(5):2416 148. [IF=6.449] Na Li et al."β-Xylosidase mutant immobilization on UiO-66-NH2 for continuous production of ginsenoside Rg1 and selective production of furfural from notoginsenoside R1."INDUSTRIAL CROPS AND PRODUCTS.2023 Jul;197:116563 147. [IF=6.656] Linying Xia et al."Panax notoginseng saponins normalises tumour blood vessels by inhibiting EphA2 gene expression to modulate the tumour microenvironment of breast cancer."PHYTOMEDICINE.2023 Mar;:154787 146. [IF=3.061] Zhu Cun et al."High nitrogen inhibits biomass and saponins accumulation in a medicinal plant Panax notoginseng."PeerJ.2023 Feb;11:e14933 145. [IF=3.568] Silu Liu et al."Evaluating the effect of ginsenoside Rg1 on CPF-induced brain injury in mice via PI3k/AKT pathway."JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY.2023 Feb;:e23319 144. [IF=3.945] Linlin Su et al."Development of SSR markers on the basis of the Panax notoginseng transcriptome for agronomic and biochemical trait association analyses."Journal of Applied Research on Medicinal and Aromatic Plants.2023 Apr;34:100475 143. [IF=5.131] Li Ling et al."Effects of Ginsenoside Rg1 on the Biological Behavior of Human Amnion-Derived Mesenchymal Stem/Stromal Cells (hAD-MSCs)."Stem Cells International.2023;2023:7074703 142. [IF=7.425] Xianqiang Chen et al."Non-thermal plasma modulation of the interaction between whey protein isolate and ginsenoside Rg1 to improve the rheological and oxidative properties of emulsion."FOOD RESEARCH INTERNATIONAL.2023 Mar;165:112548 141. [IF=14.026] Junyun Cheng et al."High-throughput transcriptional profiling of perturbations by Panax ginseng saponins and Panax notoginseng saponins using TCM-seq."Journal of Pharmaceutical Analysis.2023 Feb;: 140. [IF=4.927] Hong-Ping Wang et al."Comprehensive Identification of Ginsenosides in the Roots and Rhizomes of Panax ginseng Based on Their Molecular Features-Oriented Precursor Ions Selection and Targeted MS/MS Analysis."MOLECULES.2023 Jan;28(3):941 139. [IF=7.675] Siming Wang et al."Ginsenoside Rg1 Delays Chronological Aging in a Yeast Model via CDC19- and SDH2-Mediated Cellular Metabolism."Antioxidants.2023 Feb;12(2):296 138. [IF=5.19] Zhu, Huaisen et al."Ginsenoside Rg1 regulates thiram-induced chondrocytes’ apoptosis and angiogenesis in broiler chickens."ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH.2022 Dec;:1-15 137. [IF=4.036] Hongping Wang et al."Improving natural products identification through molecular features-oriented precursor ion selection and targeted MS/MS analysis: a case study of Zhi-Ke-Yang-Yin capsule."RSC Advances.2022 Nov;12(51):33340-33347 136. [IF=4.927] Qinhua Zheng et al."Protective Effect of Flavonoids from Mulberry Leaf on AAPH-Induced Oxidative Damage in Sheep Erythrocytes."MOLECULES.2022 Jan;27(21):7625 135. [IF=5.735] Hao Shi et al."Ginsenosides Rg1 regulate lipid metabolism and temperature adaptation in Caenorhabditis elegans."Journal of Ginseng Research.2022 Nov;: 134. [IF=0] Hong Kan et al."Identification of anti-inflammatory components in Panax ginseng of Sijunzi Decoction based on spectrum-effect relationship."Chinese Herbal Medicines.2022 Oct;: 133. [IF=2.893] Zhong Peng et al."Characterization of a novel thermophilic beta-glucosidase from Thermotoga sp. and its application in the transformation of notoginsenoside R1."3 Biotech.2022 Nov;12(11):1-14 132. [IF=3.571] Jie Mei et al."Quality evaluation of Panax notoginseng (Burk.) F.H. Chen using supercritical fluid chromatography–mass spectrometry and chemical pattern recognition."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2022 Nov;221:115029 131. [IF=5.168] Pan Wang et al."Discovery and characterization of novel ATP citrate lyase inhibitors from natural products by a luminescence-based assay."CHEMICO-BIOLOGICAL INTERACTIONS.2022 Nov;367:110199 130. [IF=5.988] Tiantian Liu et al."Study on the mechanism of American ginseng extract for treating type 2 diabetes mellitus based on metabolomics.."Frontiers in Pharmacology.2022 Sep;13:960050-960050 129. [IF=6.656] Yang Jin et al."Ginseng total saponins and Fuzi total alkaloids exert antidepressant-like effects in ovariectomized mice through BDNF-mTORC1, autophagy and peripheral metabolic pathways."PHYTOMEDICINE.2022 Sep;:154425 128. [IF=6.055] Baoyu Fu et al."Ginsenosides improve reproductive capability of aged female Drosophila through mechanism dependent on ecdysteroid receptor (ECR) and steroid signaling pathway."Frontiers in Endocrinology.2022; 13: 964069 127. [IF=6.449] Na Li et al."Enhanced conversion and extraction of ginsenoside Rg1 from Panax notoginseng using β-xylosidase mutants and an endoxylanase."INDUSTRIAL CROPS AND PRODUCTS.2022 Nov;187:115514 126. [IF=3.318] Hongda Sheng et al."Identification of bioactive ingredients from Babaodan using UPLC-QTOF-MS analysis combined with network pharmacology guided bioassays."JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES.2022 Aug;120 125. [IF=4.601] Mengying Shuai et al."Geographical origin of American ginseng (Panax quinquefolius L.) based on chemical composition combined with chemometric."JOURNAL OF CHROMATOGRAPHY A.2022 Aug;1676:463284 124. [IF=6.656] Mingrui Han et al."Single-cell transcriptomics reveals the natural product Shi-Bi-Man promotes hair regeneration by activating the FGF pathway in dermal papilla cells."PHYTOMEDICINE.2022 Jun;:154260 123. [IF=1.885] Guo Na et al."Comparison of the Saponins in Three Processed American Ginseng Products by Ultra-High Performance Liquid Chromatography-Quadrupole Orbitrap Tandem Mass Spectrometry and Multivariate Statistical Analysis."International Journal of Analytical Ch 122. [IF=6.576] Rensong Huang et al."Studies on Bioactive Components of Red Ginseng by UHPLC-MS and Its Effect on Lipid Metabolism of Type 2 Diabetes Mellitus."Frontiers in Nutrition. 2022; 9: 865070 121. [IF=6.576] Zhi-man Li et al."Transformation Mechanism of Rare Ginsenosides in American Ginseng by Different Processing Methods and Antitumour Effects."Frontiers in Nutrition. 2022; 9: 833859 120. [IF=6.53] Zhijie Chen et al."Ginsenoside Rg1 mitigates morphine dependence via regulation of gut microbiota, tryptophan metabolism, and serotonergic system function."BIOMEDICINE & PHARMACOTHERAPY. 2022 Jun;150:112935 119. [IF=4.35] Di Qu et al."Analysis of Key Chemical Components in Aqueous Extract Sediments of Panax Ginseng at Different Ages."Foods. 2022 Jan;11(8):1161 118. [IF=5.811] He Zhang et al."Prevention Effect of Protopanaxadiol-Type Saponins Saponins and Protopanaxatriol-Type Saponins on Myelosuppression Mice Induced by Cyclophosphamide.."Frontiers in Pharmacology. 2022 Apr;13:845034-845034 117. [IF=6.06] Zhu Zhu et al."Target engagement of ginsenosides in mild cognitive impairment using mass spectrometry-based drug affinity responsive target stability."J Ginseng Res. 2021 Dec;: 116. [IF=3.373] Yu Yao et al."UPLC–MS/MS method for the determination of the herb composition of Tangshen formula and the in vivo pharmacokinetics of its metabolites in rat plasma."Phytochemical Analysis. 2021 Dec 14 115. [IF=7.514] Di Qu et al."Sediment formation and analysis of the main chemical components of aqueous extracts from different parts of ginseng roots."Food Chem. 2022 Jan;:132146 114. [IF=6.06] Qingxia Huang et al."Major ginsenosides from Panax ginseng promote aerobic cellular respiration and SIRT1-mediated mitochondrial biosynthesis in cardiomyocytes and neurons."J Ginseng Res. 2022 Feb;: 113. [IF=2.419] Yinping Jin et al."Dynamic changes of ginsenosides in Panax quinquefolius fruit at different development stages measured by UHPLC-Orbitrap MS."Rapid Communications In Mass Spectrometry. 2022 Feb 17 112. [IF=5.645] Hongling Zhang et al."Characterizations of "drumstick-forming" on saponin contents of Notoginseng Radix et Rhizoma and their saccharide metabolism basis of vegetative organs of Panax notoginseng."Ind Crop Prod. 2022 Jun;180:114699 111. [IF=4.432] Shuai Zhang et al."Ginsenoside Rf inhibits human tau proteotoxicity and causes specific LncRNA, miRNA and mRNA expression changes in Caenorhabditis elegans model of tauopathy."Eur J Pharmacol. 2022 May;922:174887 110. [IF=1.662] Quan Shi et al."Ginsenoside Rg1 abolish imiquimod‐induced psoriasis‐like dermatitis in BALB/c mice via downregulating NF‐κB signaling pathway."J Food Biochem. 2019 Nov;43(11):e13032 109. [IF=1.934] Zhang Chen et al."Biotransformation of ginsenoside Rc to Rd by endophytic bacterium Bacillus sp. G9y isolated from Panax quinquefolius."Anton Leeuw Int J G. 2021 Apr;114(4):437-444 108. [IF=2.408] Fang-Tong Li et al."In Vitro Effects of Ginseng and the Seed of Zizyphus jujuba var. spinosa on Gut Microbiota of Rats with Spleen Deficiency."Chem Biodivers. 2020 Sep;17(9):e2000199 107. [IF=2.57] Chengcheng Sun et al."ShenmaYizhi Decoction Improves the Mitochondrial Structure in the Brain and Ameliorates Cognitive Impairment in VCI Rats via the AMPK/UCP2 Signaling Pathway."Neuropsych Dis Treat. 2021; 17: 1937–1951 106. [IF=3.205] Jie Tang et al."Metabolite profiling of Shuganzhi tablets in rats and pharmacokinetics study of four bioactive compounds with liquid chromatography combined with electrospray ionization tandem mass spectrometry."J Chromatogr B. 2021 Aug;1179:122827 105. [IF=3.327] Chenwen Xiao et al."Efficacy of Rg1-Oil Adjuvant on Inducing Immune Responses against Bordetella bronchiseptica in Rabbits."J Immunol Res. 2021;2021:8835919 104. [IF=3.411] Yu Jingping et al."Comprehensive Quality Evaluation of American Ginseng for Different Parts and Abnormal Trait Based on the Major Ginsenoside Contents and Morphological Characteristics."Biomed Res Int. 2021;2021:8831080 103. [IF=3.503] Jiajia Dong et al."Comparative pharmacokinetic analysis of raw and steamed Panax notoginseng roots in rats by UPLC-MS/MS for simultaneously quantifying seven saponins."Pharm Biol. 2021;59(1):653-661 102. [IF=3.645] Mengmeng Jia et al."UHPLC coupled with mass spectrometry and chemometric analysis of Kang-Ai injection based on the chemical characterization, simultaneous quantification, and relative quantification of 47 herbal alkaloids and saponins."J Sep Sci. 2020 Ju 101. [IF=3.647] Wenqi Jin et al."Ginsenoside Rd attenuates ACTH-induced corticosterone secretion by blocking the MC2R-cAMP/PKA/CREB pathway in Y1 mouse adrenocortical cells."Life Sci. 2020 Mar;245:117337 100. [IF=3.659] Zhang Sheng et al."Protective effect of Shenmai injection on doxorubicin-induced cardiotoxicity via regulation of inflammatory mediators."Bmc Complem Altern M. 2019 Dec;19(1):1-10 99. [IF=3.69] Tianyuan Yu et al."Anti-inflammation effect of Qingchang suppository in ulcerative colitis through JAK2/STAT3 signaling pathway in vitro and in vivo."J Ethnopharmacol. 2021 Feb;266:113442 98. [IF=3.69] Xiaoping Wang et al."Baoyuan decoction ameliorates apoptosis via AT1-CARP signaling pathway in H9C2 cells and heart failure post-acute myocardial infarction rats."J Ethnopharmacol. 2020 Apr;252:112536 97. [IF=3.882] Kunpeng Yin et al."Lanthanide Metal–Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine."Langmuir. 2021;37(17):5321–5328 96. [IF=3.935] Ruimei Lin et al."Global identification and determination of the major constituents in Kai-Xin-San by ultra-performance liquid chromatography-quadrupole-Orbitrap mass spectrometry and gas chromatography-mass spectrometry."J Pharmaceut Biomed. 2021 Nov;206 95. [IF=4.142] Wang Chenxi et al."Rapid discovery of potential ADR compounds from injection of total saponins from Panax notoginseng using data-independent acquisition untargeted metabolomics."Analytical And Bioanalytical Chemistry. 2021 Oct 26 94. [IF=4.268] Chan Mo et al."Ginsenoside-Rg1 acts as an IDO1 inhibitor, protects against liver fibrosis via alleviating IDO1-mediated the inhibition of DCs maturation."Phytomedicine. 2021 Apr;84:153524 93. [IF=4.36] Yongshen Ren et al."Anticoagulant active ingredients identification of total saponin extraction of different Panax medicinal plants based on grey relational analysis combined with UPLC-MS and molecular docking."J Ethnopharmacol. 2020 Oct;260:112955 92. [IF=4.411] Jianbo Chen et al."Neuroprotective Effects of Red Ginseng Saponins in Scopolamine-Treated Rats and Activity Screening Based on Pharmacokinetics."Molecules. 2019 Jan;24(11):2136 91. [IF=4.556] Meng Xu et al."Ginsenosides Rb1 and Rg1 Protect Primary Cultured Astrocytes against Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury via Improving Mitochondrial Function."Int J Mol Sci. 2019 Jan;20(23):6086 90. [IF=4.96] Manying Wang et al."20(S)-ginsenoside Rg3 promotes myoblast differentiation and protects against myotube atrophy via regulation of the Akt/mTOR/FoxO3 pathway."Biochem Pharmacol. 2020 Oct;180:114145 89. [IF=5.064] Liu Jia-qi et al."Rg1 improves LPS-induced Parkinsonian symptoms in mice via inhibition of NF-κB signaling and modulation of M1/M2 polarization."Acta Pharmacol Sin. 2020 Mar;41(4):523-534 88. [IF=5.076] Zhang Zepeng et al."Shen-Hong-Tong-Luo Formula Attenuates Macrophage Inflammation and Lipid Accumulation through the Activation of the PPAR-γ/LXR-α/ABCA1 Pathway."Oxid Med Cell Longev. 2020;2020:3426925 87. [IF=5.34] You-Ping Wu et al."Evidences for the mechanism of Shenmai injection antagonizing doxorubicin-induced cardiotoxicity."Phytomedicine. 2021 Jul;88:153597 86. [IF=5.34] Gui Zhou et al."Effects of Qing Chang Suppository Powder and its Ingredients on IL-17 Signal Pathway in HT-29 Cells and DSS-induced Mice."Phytomedicine. 2021 Jul;87:153573 85. [IF=5.34] Shangmin Yu et al."nNovel insights into antidepressant mechanism of Kai Xin San formula: inhibiting NLRP3 inflammasome activation by promoting autophagy."Phytomedicine. 2021 Oct;:153792 84. [IF=5.396] Hui Wang et al."Ginsenoside extract from ginseng extends lifespan and health span in Caenorhabditis elegans."Food Funct. 2021 Aug;12(15):6793-6808 83. [IF=5.455] Yin Shi-Jun et al."Antithrombotic effect and action mechanism of Salvia miltiorrhiza and Panax notoginseng herbal pair on the zebrafish."Chin Med-Uk. 2020 Dec;15(1):1-10 82. [IF=5.878] Jianbo Chen et al."Protection by ginseng saponins against cyclophosphamide-induced liver injuries in rats by induction of cytochrome P450 expression and mediation of the l-arginine/nitric oxide pathway based on metabolomics."Phytother Res. 2021 Jun;35(6): 81. [IF=6.06] Zhenzhuo Li et al."Ginsenosides repair UVB-induced skin barrier damage in BALB/c hairless mice and HaCaT keratinocytes."J Ginseng Res. 2021 May;: 80. [IF=6.558] Qingqing Song et al."Binary code, a flexible tool for diagnostic metabolite sequencing of medicinal plants."Anal Chim Acta. 2019 Dec;1088:89 79. [IF=1.785] Fengyu Li et al."Ginsenoside Rg1 prevents starvation‑induced muscle protein degradation via regulation of AKT/mTOR/FoxO signaling in C2C12 myotubes."Exp Ther Med. 2017 Aug;14(2):1241-1247 78. [IF=1.967] Meijia Li et al."Brain Concentration of Ginsenosides and Pharmacokinetics after Oral Administration of Mountain-cultivated Ginseng."J Chin Chem Soc-Taip. 2017 Apr;64(4):395-403 77. [IF=3.205] Naijing Li et al."Protective effects of ginsenosides Rg1 and Rb1 on an Alzheimer's disease mouse model: A metabolomics study."J Chromatogr B. 2015 Mar;985:54 76. [IF=3.998] Bian Minjuan et al."Combination of ginsenoside Rb1 and Rd protects the retina against bright light-induced degeneration."Sci Rep-Uk. 2017 Jul;7(1):1-15 75. [IF=4.36] Bin Ma et al."Sulfur fumigation reducing systemic exposure of ginsenosides and weakening immunomodulatory activity of ginseng."J Ethnopharmacol. 2017 Jan;195:222 74. [IF=4.546] Huimin Liu et al."Antiobesity Effects of Ginsenoside Rg1 on 3T3-L1 Preadipocytes and High Fat Diet-Induced Obese Mice Mediated by AMPK."Nutrients. 2018 Jul;10(7):830 73. [IF=4.952] Jiali Chen et al."Ginsenosides and amino acids in flavored ginseng chips as affected by food formulation and processing technology."Lwt Food Sci Technol. 2015 Jun;62:517 72. [IF=5.34] Shan-Shan Zhou et al."Stronger anti-obesity effect of white ginseng over red ginseng and the potential mechanisms involving chemically structural/compositional specificity to gut microbiota."Phytomedicine. 2020 Aug;74:152761 71. [IF=6.06] Yang Xiu et al."Simultaneous determination and difference evaluation of 14 ginsenosides in Panax ginseng roots cultivated in different areas and ages by high-performance liquid chromatography coupled with triple quadrupole mass spectrometer in the multipl 70. [IF=6.06] Jianbo Chen et al."Effects of processing method on the pharmacokinetics and tissue distribution of orally administered ginseng."J Ginseng Res. 2018 Jan;42:27 69. [IF=6.06] Jiahong Han et al."Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis."J Ginseng Res. 2020 Mar;44:291 68. [IF=6.06] Naijing Li et al."A UPLC/MS-based metabolomics investigation of the protective effect of ginsenosides Rg1 and Rg2 in mice with Alzheimer's disease."J Ginseng Res. 2016 Jan;40:9 67. Manying Wang, Jixiang Ren, Xuenan Chen, Jianzeng Liu, Xiaohao Xu, Xiangyan Li, Daqing Zhao, Liwei Sun, 20(S)-ginsenoside Rg3 promotes myoblast differentiation and protects against myotube atrophy via regulation of the Akt/mTOR/FoxO3 pathway, Biochemical Ph 66. Yongshen Ren, Jiao Ai, Xinqiao Liu, Shuai Liang, Yao Zheng, Xin Deng, Yan Li, Jing Wang, Xukun Deng, Lin-Lin Chen, Anticoagulant active ingredients identification of total saponin extraction of different Panax medicinal plants based on grey relational anal 65. Wang, Xiaoping, et al. "Baoyuan decoction ameliorates apoptosis via AT1-CARP signaling pathway in H9C2 cells and heart failure post-acute myocardial infarction rats." Journal of ethnopharmacology 252 (2020): 112536.https://doi.org/10.1016/j.jep.2019.112536 64. Jin, Wenqi, et al. "Ginsenoside Rd attenuates ACTH-induced corticosterone secretion by blocking the MC2R-cAMP/PKA/CREB pathway in Y1 mouse adrenocortical cells." Life sciences 245 (2020): 117337.https://doi.org/10.1016/j.lfs.2020.117337 63. Bian, Minjuan, et al. "Combination of ginsenoside Rb1 and Rd protects the retina against bright light-induced degeneration." Scientific reports 7.1 (2017): 1-15.https://doi.org/10.1038/s41598-017-06471-x 62. Zhou, Qi, et al. "Ginsenoside Rg1 inhibits platelet activation and arterial thrombosis." Thrombosis research 133.1 (2014): 57-65.https://doi.org/10.1016/j.thromres.2013.10.032 61. Liu, Huimin, et al. "Antiobesity effects of ginsenoside Rg1 on 3T3-L1 preadipocytes and high fat diet-induced obese mice mediated by AMPK." Nutrients 10.7 (2018): 830.https://doi.org/10.3390/nu10070830 60. Yu, Jingping, et al. "Comprehensive Quality Evaluation of American Ginseng for Different Parts and Abnormal Trait Based on the Major Ginsenoside Contents and Morphological Characteristics." BioMed research international 2021 (2021).https://doi.org/10.1155/ 59. Chen, Jiali, et al. "Ginsenosides and amino acids in flavored ginseng chips as affected by food formulation and processing technology." LWT-Food Science and Technology 62.1 (2015): 517-524.https://doi.org/10.1016/j.lwt.2014.10.047 58. Naijing Li, Ying Liu, Wei Li, Ling Zhou, Qing Li, Xueqing Wang, Ping He, A UPLC/MS-based metabolomics investigation of the protective effect of ginsenosides Rg1 and Rg2 in mice with Alzheimer's disease, Journal of Ginseng Research, Volume 40, Issue 1, 2016 57. Joo, Kyung-Mi, et al. "Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method." Journal of pharmaceutical and biomedical analysis 51.1 (20 56. 李美玲,彭健玲,江海都,柴胜丰,朱成豪,熊忠臣.9种金花茶花抗氧化活性及其主要活性物质含量的研究[J].广西科学院学报,2020,36(04):419-426. 55. 邵紫君,李志满,于鹏程,陈建波,李珊珊,孙印石.氨基酸转化三七花中稀有人参皂苷及提取液对脂多糖诱导的RAW264.7细胞活性的影响[J].中草药,2021,52(03):702-710. 54. 越皓,周东月,张美玉,张琰,戴雨霖,郑飞,朱英豪.红参中原人参三醇型皂苷组在肠道菌群中体外转化及对肠道菌群的作用[J].应用化学,2021,38(03):323-330. 53. 屈文佳,贾天颖,王海丽,辛洁萍,王敏,白玉莹,徐文娟,李向日.不同蒸制时间下红参颜色及3种常见人参皂苷的转化规律研究[J].北京中医药大学学报,2020,43(09):769-775. 52. 赵宏月,张东伟,庞琳琳,张欢,于睿.黄芪甲苷及人参皂苷Rg1对高脂大鼠心肌缺血再灌注损伤后心肌细胞凋亡的影响[J].辽宁中医杂志,2021,48(02):188-191. 51. 吴冬雪,王秋颖,王淑敏,陈思键,刘淑莹,赵幻希,修洋.人参皂苷的仿生提取研究[J].分析试验室,2021,40(02):145-149. 50. 徐文,周妍,朱国旗.人参皂苷Rg1抑制小鼠实验性自身免疫性脑脊髓炎的作用及免疫机制[J].安徽中医药大学学报,2021,40(01):76-81. 49. 屈青松,林峰,赵崇妍,马涛,宋帅,史新元.发酵乳杆菌发酵人参工艺优化及人参皂苷抗氧化活性测定[J].中成药,2020,42(10):2738-2743. 48. 胡小松. 五灵脂中菌群种类及其生物转化作用初步研究[D].北京中医药大学,2020. 47. 张娜,黄鑫,郭云龙,越皓,刘淑莹.基于UPLC-QQQ-MS多指标统计分析研究不同生境人参中皂苷分布[J].特产研究,2020,42(06):48-54. 46. 王艳,尉忠贤,李晶.HPLC法测定不同厂家振源片中人参皂苷的含量[J].西北药学杂志,2020,35(05):669-673. 45. 杜姝,姜岩,刘晶,薛智欣.人参皂苷Rg1对癫痫大鼠海马神经元损伤和小胶质细胞活化的影响[J].免疫学杂志,2021,37(03):202-209. 44. 张涛,王冠,张维维,陈湘,张庆贺,刘芳馨,李卓然,齐伟辰.温度调控对人参皂苷积累及其关键酶基因表达的影响[J].中草药,2020,51(19):5035-5040. 43. 夏晚霞, 张尚微, 葛亚中,等. 乳酸菌发酵转化人参皂苷[J]. 现代食品科技, 2018, 34(09):136-142. 42. 杨林, 徐晓珍, 陈劲柏,等. UHPLC法同时测定参麦注射液中8种人参皂苷[J]. 中成药, 2019. 41. 李雪晴, 李丽, 刘秀峰,等. 三七皂苷的人肠道菌群体外代谢研究[J]. 药物生物技术, 2017(03):34-39. 40. 赵昶灵, 杨生超, 陈中坚,等. 紫,绿三七的总花色苷和总皂苷含量及皂苷单体组成[J]. 中药材, 2014, 37(10):1749-1753. 39. 苗瑞, 吴冬雪, 王秋颖,等. 基于多壁碳纳米管的人参皂苷快速分离[J]. 高等学校化学学报, 2018. 38. 张初瑜 陈素红 吴素香. 一测多评法测定复方人参片中的8种苷类成分[J]. 中国现代应用药学 2018 35(05):90-96. 37. 刘喆, 郭云龙, 许庆轩,等. 瓜子壳作为新型木质电喷雾材料的分析性能研究[J]. 分析化学, 2019(9). 36. 张艳欣, 朱国琴, 王丹丹. 均匀设计法优化林下山参中人参皂苷提取工艺的研究[J]. 上海医药, 2019, 040(015):89-92. 35. 张东伟,赵宏月,李全生,杨关林,闵冬雨,宋囡,张会永,贾连群,张哲,曹慧敏.黄芪甲苷及人参皂苷Rg1对高脂大鼠心肌缺血再灌注损伤后心肌线粒体自噬的影响[J].中华中医药学刊,2020,38(03):60-64. 34. 郭晨旭, 钱军, 李靖,等. 高效液相色谱法确定兔人参药物血清制作中的灌药周期研究[J]. 蚌埠医学院学报, 2015, 40(6). 33. 刘润花, 孙雨, 倪诗婷,等. 高效液相色谱法测定消痞和胃胶囊中三七有效成分的含量[J]. 中南药学, 2020, v.18;No.173(06):104-107. 32. 穆艳月,景原媛,于泳浩.鞘内注射人参皂苷Rg_1对关节炎慢性吗啡耐受大鼠谷氨酸转运体水平的影响[J].中国中西医结合杂志,2012,32(11):1539-1542. 31. 张琰, 李方彤, 韩铭鑫,等. 通过RRLC-Q-TOF MS和UPLC-QQQ MS分析原人参三醇型皂苷在人肠道菌群中的代谢产物[J]. 质谱学报, 2020(1):66-75. 30. 冯焕琴[1, 2 ] 徐雪风[1, 2 ] 杨宏伟[1, 2 ] 沈宝云[3] 胡静[3] 李朝周[1, 2 ]. 藜麦种子皂苷不同提取方法的比较研究[J]. 食品工业科技, 2016(37):221. 29. 张淼, 李梦娇, 高敬林,等. 药物制剂中月桂醇磷酸酯钾的新型处理方法及对水溶性药物成分表征的影响[J]. 中国医院药学杂志, 2017(18). 28. 王忠萍, 张静, 陈运中. 苦瓜总皂苷的响应面法提取条件及降血糖活性的研究[J]. 时珍国医国药, 2019(12). 27. 于颖超, 倪健, 陈功森,等. 芪箭颗粒中皂苷类成分与莫诺苷的指纹图谱研究[J]. 中南药学, 2019(12). 26. 吴雨佳, 王令充, 张雯,等. 生物黏附性三七总皂苷-白及多糖-海藻酸钠复合微球的制备及表征[J]. 中草药, 2019, v.50;No.655(20):49-56. 25. 张博, 孙秀丽, 郭云龙,等. 液质联用技术分析不同产地不同年限人参的化学成分[J]. 中国实验方剂学杂志, 2020年26卷8期, 206-212页, ISTIC PKU CSCD CA, 2020. 24. 孙婉瑾, 金实, 白书仙,等. 消肿Ⅰ号膏剂的高效液相指纹图谱研究[J]. 华西药学杂志, 2019, v.34(06):72-75. 23. 孔昊存, 栾广忠, 师帅,等. 木糖醇苦瓜果脯加工工艺研究[J]. 食品科技, 2015, 040(004):165-169. 22. 周洪伟, 周曼, 侯德岩,等. 星点设计-效应面法优化人参皂苷Rg1脂质体的制备工艺[J]. 中医药信息, 2011, 28(004):38-41. 21. 刘芳, 赵瀚森, 孙公伟,等. 基质辅助激光解析质谱成像可视化分析三七皂苷空间分布. 20. 吴冬雪,刘淑莹,陈思键,赵幻希,修洋,王淑敏.固相萃取结合高效液相色谱-三重四极杆质谱快速分离检测益气养血口服液中人参皂苷的新方法[J].分析测试学报,2020,39(07):867-873. 19. LU Zhaochen LI Mengjiao LIU Di 等. 分散液液萃取-HPLC测定中药化妆品中皂苷含量[J]. 中国现代应用药学 2019 036(011):1370-1374. 18. 郑尧. 人参鲜药干制/复水过程水分状态与化学成分变化规律研究[J]. 中草药 2019(14):3302-3312. 17. 杨丹 黄娟 彭娟 等. 人参皂苷Rg1微球的制备及实验优化[J]. 影像研究与医学应用 2019 003(022):P.240-242. 16. 徐国超 高岩 马爽 等. 人参皂苷Rg1促进C2C12细胞增殖与分化[J]. 东北师大学报(自然科学版) 2018 050(004):121-125. 15. 孙孔春 吴乐艳 侯雯清 等. 云南省不同产地三七的成分分析[J]. 昆明医科大学学报 2020 041(001):P.1-10. 14. 袁明洋 金司仪 黄壮 等. 不同粒度对三七粉主要有效成分体外溶出度的影响[J]. 食品安全质量检测学报 2020 v.11(06):234-238. 13. 刘梦楠 薛雪 熊慧 等. 不同净制工艺对三七质量的影响[J]. 世界中医药 2019 v.14(02):56-59+64. 12. 张洪玲 赵昶灵 曾晓玲 等. 三七绿紫过渡茎可溶性糖和蛋白质及花色苷和三萜皂苷的含量[J]. 贵州农业科学 2019 v.47;No.342(02):113-117. 11. 穆婷 赵昶灵 陈中坚 文国松 杨生超 魏富刚 肖兴磊 王崇德.三七绿紫过渡地上茎的花色苷和皂苷组织定位及其含量分析[J].西北植物学报 2016 36(09):1772-1780. 10. 赵昶灵 陈中坚 余育启 等. 三七紫 绿茎植株营养器官在不同生长阶段的花色苷和皂苷含量及其相关性[J]. 中药材 2016 039(009):1923-1929. 9. 赵昶灵 文国松 陈中坚 丁灿 张丽梅 魏富刚 臧灵飞 李正辉.三七地上茎紫化双茎化和地下部总皂苷含量之间的相关性[J].时珍国医国药 2018 29(03):690-693. 8. 臧灵飞 张洪玲 杨迪 赵鹏宇 赵昶灵 李桂琼 古朝山 张优 顾凡 陈杞临.三七地上茎4个转录因子基因转录水平的纵向变化及其与总三萜皂苷含量的关系[J].贵州农业科学 2020 48(05):31-36. 7. 朱美旗 刘雪懿 钱文强 张立翱 杨阳.三七中人参皂苷Rg1的不同提取工艺对比[J].生物化工 2020 6(03):36-41. 6. 赵昶灵 孙艳 陈中坚 魏富刚 文国松 唐小华 肖兴磊 李孙文.三七一年生紫、绿地上茎植株营养器官花色苷和皂苷含量对冰水模拟低温胁迫的响应[J].时珍国医国药 2016 27(10):2492-2496. 5. 王灿灿 戴黎蓉 赵旻 等. UPLC法同时测定四君子汤中7种化学成分的含量[J]. 沈阳药科大学学报 2018 v.35；No.271(08):639-645. 4. 张永 陈旭 丁越 等. HPLC法结合统计学方法研究复方丹参片中皂苷类成分[J]. 辽宁中医杂志 2019 46(01):126-129. 3. 杨丽颖 郭伟英. HPLC-ELSD法同时测定益心宁神片中5种成分的含量[J]. 中药材 2015 38(012):2619-2622. 2. 周静 叶朝晖 吴燕华. HPLC-ELSD同时测定铁破锣中3种三萜皂苷含量及体外抗氧化性研究[J]. 药学实践杂志 2019(4). 1. 赵立春 刘继永. Box-Behnken法优化人参皂苷Rg1 Re Rb1提取工艺[J]. 食品工业 2020(1).