KB-R7943 mesylate 98%

2-[2-[4-(4-Nitrobenzyloxy)Phenyl]Ethyl]Isothiourea Mesylate

源叶(MedMol)
S80482
182004-65-5
C17H21N3O6S2
427.495
KB-R7943 甲磺酸盐; 2-[2-[4-(4-硝基苄氧基)苯基]乙基]异硫脲甲烷磺; S-[4-[(4-硝基苄基)氧代]苯乙基]异硫脲甲磺酸盐;;Carbamimidothioic Acid 4-[(4-Nitrobenzyl)oxy]phenethyl Ester Methanesulfonate; KB-R7943 mesylate; 4-[(4-Nitrobenzyl)oxy]phen
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S80482-5mg 98% ¥320.00元 4 - - -
源叶(MedMol) S80482-10mg 98% ¥480.00元 10 - - -
源叶(MedMol) S80482-50mg 98% ¥1200.00元 >10 - - -
产品介绍 参考文献(1篇) 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 µM. KB-R7943 mesylate induces cancer cell death via activating the JNK pathway and blocking autophagic flux.
产品描述: KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 µM. KB-R7943 mesylate induces cancer cell death via activating the JNK pathway and blocking autophagic flux.
靶点: IC50: 5.7±2.1 µM (Na+/Ca2+ exchanger);Na+/Ca2+Exchanger;Autophagy
参考文献: 1. Brustovetsky T, et al. KB-R7943, an inhibitor of the reverse Na+ /Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex I. Br J Pharmacol. 2011 Jan;162(1):255-70. 2. Barrientos G, et al. The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate(KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels. Mol Pharmacol. 2009 Sep;76(3):560-8. 3. Cheng H, et al. High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943. Br J Pharmacol. 2012 Apr;165(7):2260-73. 4. Long Z, et al. The reverse-mode NCX1 activity inhibitor KB-R7943 promotes prostate cancer cell death by activating the JNK pathway and blocking autophagic flux. Oncotarget. 2016;7(27):42059-70.
溶解性: DMSO  :  100  mg/mL  (233.92  mM;  Need  ultrasonic)
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.339 ml 11.696 ml 23.392 ml
5 mM 0.468 ml 2.339 ml 4.678 ml
10 mM 0.234 ml 1.17 ml 2.339 ml
50 mM 0.047 ml 0.234 ml 0.468 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

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