ZSTK474 99%

ZSTK474

源叶(MedMol)
S80736
475110-96-4
C19H21F2N7O2
417.42
2-(2-二氟甲基苯并咪唑-1-基)-4,6-二吗啉基-1,3,5-三嗪;ZSTK-474
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S80736-5mg 99% ¥200.00元 6 - - -
源叶(MedMol) S80736-10mg 99% ¥230.00元 4 - - -
源叶(MedMol) S80736-25mg 99% ¥300.00元 6 - - -
源叶(MedMol) S80736-50mg 99% ¥400.00元 5 - - -
源叶(MedMol) S80736-100mg 99% ¥750.00元 5 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

ZSTK474 is an ATP-competitive pan-class I PI3K inhibitor with IC50s of16 nM, 44 nM, 4.6 nM and 49 nM for PΙ3Κα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.
产品描述: ZSTK474 is an ATP-competitive pan-class I PI3K inhibitor with IC50s of16 nM, 44 nM, 4.6 nM and 49 nM for PΙ3Κα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.
靶点: PI3Kδ:4.6 nM (IC50);PI3Kα:16 nM (IC50);PI3Kβ:44 nM (IC50);PI3Kγ:49 nM (IC50);Autophagy ;PI3K;Autophagy
体内研究: In mice subjected to MCAO, treatment with ZSTK474 is tested at dosages of 50, 100, 200, and 300 mg/kg. Since the 200 mg/kg dose produces significant improvement and no obvious toxic effects (P<0.01), mice are treated with ZSTK474 at a dose of 200 mg/kg/day daily for three post-MCAO days during the remaining experiments of this study. Neurological function is examined in mice suffered from MCAO followed by 24, 48, and 72 h of reperfusion. In the ZSTK474 group, neurological function scores are significantly better than the control group except the corner test
参考文献: 1. Kong D, et al. ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms. Cancer Sci, 2007, 98(10), 1638-1642. 2. Liu F, et al. Prolonged inhibition of class I PI3K promotes liver cancer stem cell expansion by augmenting SGK3/GSK-3β/β-catenin signalling. J Exp Clin Cancer Res. 2018 Jun 25;37(1):122. 3. Wang P, et al. Class I PI3K inhibitor ZSTK474 mediates a shift in microglial/macrophage phenotype and inhibits inflammatory response in mice with cerebral ischemia/reperfusion injury. J Neuroinflammation. 2016 Aug 22;13(1):192.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.396 ml 11.978 ml 23.957 ml
5 mM 0.479 ml 2.396 ml 4.791 ml
10 mM 0.24 ml 1.198 ml 2.396 ml
50 mM 0.048 ml 0.24 ml 0.479 ml
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参考文献

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