ZSTK474

99.70%

ZSTK474

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品牌：源叶(MedMol)

产品编号：S80736 一键复制产品信息

CAS号：475110-96-4

分子式：C₁₉H₂₁F₂N₇O₂

分子量：417.42

别名：2-(2-二氟甲基苯并咪唑-1-基)-4,6-二吗啉基-1,3,5-三嗪;ZSTK-474

货号	规格	价格	上海	北京	珠海	重庆	武汉
S80736-5mg	99.70%	￥200.00 S80736-5mg ￥200.00 现货	6 6	-	-	-	-
S80736-10mg	99.70%	￥230.00 S80736-10mg ￥230.00 现货	4 4	-	-	-	-
S80736-25mg	99.70%	￥300.00 S80736-25mg ￥300.00 现货	6 6	-	-	-	-
S80736-50mg	99.70%	￥400.00 S80736-50mg ￥400.00 现货	5 0 5	-	-	-	-
S80736-100mg	99.70%	￥750.00 S80736-100mg ￥750.00 现货	4 4	-	-	-	-

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产品介绍参考文献质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

ZSTK474 is an ATP-competitive pan-class I PI3K inhibitor with IC50s of16 nM, 44 nM, 4.6 nM and 49 nM for PΙ3Κα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.

靶点：

PI3Kδ:4.6 nM (IC50);PI3Kα:16 nM (IC50);PI3Kβ:44 nM (IC50);PI3Kγ:49 nM (IC50);Autophagy ;PI3K;Autophagy

体内研究：

In mice subjected to MCAO, treatment with ZSTK474 is tested at dosages of 50, 100, 200, and 300 mg/kg. Since the 200 mg/kg dose produces significant improvement and no obvious toxic effects (P<0.01), mice are treated with ZSTK474 at a dose of 200 mg/kg/day daily for three post-MCAO days during the remaining experiments of this study. Neurological function is examined in mice suffered from MCAO followed by 24, 48, and 72 h of reperfusion. In the ZSTK474 group, neurological function scores are significantly better than the control group except the corner test

参考文献：

1. Kong D, et al. ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms. Cancer Sci, 2007, 98(10), 1638-1642. 2. Liu F, et al. Prolonged inhibition of class I PI3K promotes liver cancer stem cell expansion by augmenting SGK3/GSK-3β/β-catenin signalling. J Exp Clin Cancer Res. 2018 Jun 25;37(1):122. 3. Wang P, et al. Class I PI3K inhibitor ZSTK474 mediates a shift in microglial/macrophage phenotype and inhibits inflammatory response in mice with cerebral ischemia/reperfusion injury. J Neuroinflammation. 2016 Aug 22;13(1):192.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.396 ml	11.978 ml	23.957 ml
5 mM	0.479 ml	2.396 ml	4.791 ml
10 mM	0.24 ml	1.198 ml	2.396 ml
50 mM	0.048 ml	0.24 ml	0.479 ml