| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S80931-5mg |
≥99% | ￥204.00 | 货期：2-3天 | - | - | - |
|
S80931-10mg |
99.5% | ￥272.00 | 8 | - | - | - |
|
S80931-25mg |
≥99% | ￥489.60 | 货期：2-3天 | - | - | - |
|
S80931-50mg |
≥99% | ￥680.00 | 货期：2-3天 | - | - | - |
|
S80931-100mg |
99.5% | ￥1224.00 | 3 | - | - | - |
|
S80931-200mg |
≥99% | ￥2380.00 | 货期：2-3天 | - | - | - |
|
S80931-250mg |
≥99% | ￥2720.00 | 货期：2-3天 | - | - | - |
|
VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β
| 产品描述： | VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | p38α MAPK;p38MAPK;Autophagy | ||||||||||||||||||||
| 体内研究： | The half-life of VX-702 is 16 to 20 hours, with a median clearance of 3.75 L/h and a volume of distribution of 73 L/kg. Both AUC and Cmax values are dose proportional for VX-702, which is predominantly cleared renally. VX-702 (at a dose of 0.1 mg/kg twice daily) has an equivalent effect as that of methotrexate (0.1 mg/kg). In addition, VX-702 (5 mg/kg twice daily) also has an equivalent effect as prednisolone (10 mg/kg once daily), as measured by percentage inhibition of wrist joint erosion and inflammation score. | ||||||||||||||||||||
| 参考文献： | 1. Kuliopulos A, et al. Effect of selective inhibition of the p38 MAP kinase pathway on platelet aggregation. Thromb Haemost, 2004, 92(6), 1387-1393. 2. Braddock M, IDDB Meeting Report, 2005, March 14-15. 3. Gill A, IDDB Meeing Report, 2002, March 06-08. 4. Naka K, et al. Dipeptide species regulate p38MAPK-Smad3 signalling to maintain chronic myelogenous leukaemia stem cells. Nat Commun. 2015 Aug 20;6:8039. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 42 mg/mL (103.88 mM) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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