VX-702

    99%

VX-702

源叶(MedMol)
S80931
745833-23-2
C19H12F4N4O2
404.32
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S80931-5mg 99% ¥204.00元 1 - - -
源叶(MedMol) S80931-10mg 99% ¥272.00元 8 - - -
源叶(MedMol) S80931-25mg 99% ¥489.60元 预计交期:2-3天 - - -
源叶(MedMol) S80931-50mg 99% ¥680.00元 预计交期:2-3天 - - -
源叶(MedMol) S80931-100mg 99% ¥1224.00元 3 - - -
源叶(MedMol) S80931-200mg 99% ¥2380.00元 预计交期:2-3天 - - -
源叶(MedMol) S80931-250mg 99% ¥2720.00元 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β
产品描述: VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β
靶点: p38α MAPK;p38MAPK;Autophagy
体内研究: The half-life of VX-702 is 16 to 20 hours, with a median clearance of 3.75 L/h and a volume of distribution of 73 L/kg. Both AUC and Cmax values are dose proportional for VX-702, which is predominantly cleared renally. VX-702 (at a dose of 0.1 mg/kg twice daily) has an equivalent effect as that of methotrexate (0.1 mg/kg). In addition, VX-702 (5 mg/kg twice daily) also has an equivalent effect as prednisolone (10 mg/kg once daily), as measured by percentage inhibition of wrist joint erosion and inflammation score.
参考文献: 1. Kuliopulos A, et al. Effect of selective inhibition of the p38 MAP kinase pathway on platelet aggregation. Thromb Haemost, 2004, 92(6), 1387-1393. 2. Braddock M, IDDB Meeting Report, 2005, March 14-15. 3. Gill A, IDDB Meeing Report, 2002, March 06-08. 4. Naka K, et al. Dipeptide species regulate p38MAPK-Smad3 signalling to maintain chronic myelogenous leukaemia stem cells. Nat Commun. 2015 Aug 20;6:8039.
溶解性: DMSO  :  ≥  42  mg/mL  (103.88  mM)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.473 ml 12.366 ml 24.733 ml
5 mM 0.495 ml 2.473 ml 4.947 ml
10 mM 0.247 ml 1.237 ml 2.473 ml
50 mM 0.049 ml 0.247 ml 0.495 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

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