Isradipine

    99%

Isradipine

源叶(MedMol)
S80941
75695-93-1
C19H21N3O5
371.39
伊拉地平;易拉地平;导脉顺;3-isopropyl 5-methyl 4-(benzo[c][1,2,5]oxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S80941-10mg 99% ¥340.00元 9 - - -
源叶(MedMol) S80941-50mg 99% ¥850.00元 >10 - - -
源叶(MedMol) S80941-250mg 99% ¥1450.00元 5 - - -
源叶(MedMol) S80941-1g 99% ¥3200.00元 3 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease
产品描述: Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease
靶点: L-type calcium channel;CalciumChannel;Autophagy
体内研究: Isradipine (0.1~3 mg/kg; p.o.) makes sodium excretion increase in a dose-dependent manner. Isradipine pre-treatment reduces 6-hydroxydopamine induced neurotoxicity at the striatal level. Protective effect of isradipine at the striatal level is dose-dependent as shown from 6 mice. Isradipine pre-treatment increases the number of surviving SNc DA cells after 6-hydroxydopamine induced degeneration. Isradipine is capable of protecting striatal dopaminergic terminals and SNc dopaminergic cell bodies against a slow, progressive insult created by intrastriatal injection of 6-hydroxydopamine.
参考文献: 1. Ilijic E, et al. The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease. Neurobiol Dis. 2011;43(2):364-371. 2. Campbell CA, et al. Effects of isradipine, an L-type calcium channel blocker on permanent and transient focal cerebral ischemia in spontaneously hypertensive rats. Exp Neurol. 1997;148(1):45-50. 3. Hof RP, et al. Selective effects of PN 200-110 (isradipine) on the peripheral circulation and the heart. Am J Cardiol. 1987;59(3):30B-36B.
溶解性: DMSO  :  ≥  100  mg/mL  (269.26  mM)
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.693 ml 13.463 ml 26.926 ml
5 mM 0.539 ml 2.693 ml 5.385 ml
10 mM 0.269 ml 1.346 ml 2.693 ml
50 mM 0.054 ml 0.269 ml 0.539 ml
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参考文献

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