产品描述: | Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease |
靶点: |
L-type calcium channel;CalciumChannel;Autophagy |
体内研究: |
Isradipine (0.1~3 mg/kg; p.o.) makes sodium excretion increase in a dose-dependent manner. Isradipine pre-treatment reduces 6-hydroxydopamine induced neurotoxicity at the striatal level. Protective effect of isradipine at the striatal level is dose-dependent as shown from 6 mice. Isradipine pre-treatment increases the number of surviving SNc DA cells after 6-hydroxydopamine induced degeneration. Isradipine is capable of protecting striatal dopaminergic terminals and SNc dopaminergic cell bodies against a slow, progressive insult created by intrastriatal injection of 6-hydroxydopamine. |
参考文献: |
1. Ilijic E, et al. The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease. Neurobiol Dis. 2011;43(2):364-371. 2. Campbell CA, et al. Effects of isradipine, an L-type calcium channel blocker on permanent and transient focal cerebral ischemia in spontaneously hypertensive rats. Exp Neurol. 1997;148(1):45-50. 3. Hof RP, et al. Selective effects of PN 200-110 (isradipine) on the peripheral circulation and the heart. Am J Cardiol. 1987;59(3):30B-36B. |
溶解性: |
DMSO : ≥ 100 mg/mL (269.26 mM) |
保存条件: |
2-8℃ |
配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
1 mM |
2.693 ml |
13.463 ml |
26.926 ml |
5 mM |
0.539 ml |
2.693 ml |
5.385 ml |
10 mM |
0.269 ml |
1.346 ml |
2.693 ml |
50 mM |
0.054 ml |
0.269 ml |
0.539 ml |
|
注意: |
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