Oprozomib (ONX 0912) 99%

Oprozomib (ONX 0912)

源叶(MedMol)
S81123
935888-69-0
C25H32N4O7S
532.61
ONX-0912;ONX0912;ONX 0912;PR-047;PR047;PR 047
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S81123-1mg 99% ¥104.00元 6 - - -
源叶(MedMol) S81123-2mg 99% ¥180.00元 5 - - -
源叶(MedMol) S81123-5mg 99% ¥415.00元 6 - - -
源叶(MedMol) S81123-10mg 99% ¥660.00元 4 - - -
源叶(MedMol) S81123-25mg 99% ¥1490.00元 4 - - -
源叶(MedMol) S81123-50mg 99% ¥2650.00元 预计交期:2-3天 - - -
源叶(MedMol) S81123-100mg 99% ¥4200.00元 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Oprozomib (PR-047) is an orally bioavailable and selective peptide epoxyketone proteasome inhibitor with IC50s of 36 and 82 nM for proteasome (β5) and immunoproteasome (LMP7), respectively. Oprozomib (ONX 0912) induces apoptosis in MM cells
产品描述: Oprozomib (PR-047) is an orally bioavailable and selective peptide epoxyketone proteasome inhibitor with IC50s of 36 and 82 nM for proteasome (β5) and immunoproteasome (LMP7), respectively. Oprozomib (ONX 0912) induces apoptosis in MM cells
靶点: Proteasome;Autophagy;Apoptosis;Proteasome; Autophagy
体内研究: Oprozomib (PR-047) selectively inhibits chymotrypsin-like (CT-L) activity of both the constitutive proteasome (β5) and immunoproteasome (LMP7) and demonstrates an absolute bioavailability of up to 39% in rodents and dogs. Oprozomib promotes antitumor activity in multiple animal models by oral administration at doses below the maximum tolerated dose (MTD). Oprozomib (30 mg/kg by oral gavage once daily for 5 consecutive days followed by 2 days of rest) treatment decreases tumor burden in C57Bl/6 and NOD.SCID.IL2Rγ-/- mice.
参考文献: 1. Han-Jie Zhou, et al. Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047). J Med Chem. 2009 May 14;52(9):3028-38. 2. Dharminder Chauhan,et al. A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma. Blood. 2010 Dec 2;116(23):4906-15. 3. M A Hurchla, et al.The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects. Leukemia. 2013 Feb;27(2):430-40.
溶解性: DMSO  :  ≥  50  mg/mL  (93.88  mM)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 1.878 ml 9.388 ml 18.775 ml
5 mM 0.376 ml 1.878 ml 3.755 ml
10 mM 0.188 ml 0.939 ml 1.878 ml
50 mM 0.038 ml 0.188 ml 0.376 ml
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参考文献

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