lithospermic acid B 99%

lithospermic acid B

源叶(MedMol)
S81239
121521-90-2
C36H30O16
718.614
丹酚酸 B;紫草酸B;SALVIANOLIC ACID B;LITHOSPERMIC ACID B;DANFENSUAN B;丹酚酸 B, 来源于丹参;Lithospermic acid B;3-(1-Carboxy-2-(3,4-dihydroxyphenyl)ethyl) 4-(3-(1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy)-3-oxo-1-propen
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S81239-5mg 99% ¥380.00元 2 - - -
源叶(MedMol) S81239-25mg 99% ¥1300.00元 预计交期:2-3天 - - -
产品介绍 参考文献(1篇) 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Salvianolic acid B is an active ingredient of Salvia miltiorrhiza, which has been widely applied in China for the management of various microcirculation-related disorders, such as cardiovascular disease, cerebrovascular disease, and diabetic vascular complication.
产品描述: Salvianolic acid B is an active ingredient of Salvia miltiorrhiza, which has been widely applied in China for the management of various microcirculation-related disorders, such as cardiovascular disease, cerebrovascular disease, and diabetic vascular complication.
靶点: Autophagy;Sirtuin; Autophagy
体内研究: Salvianolic acid B (SalB) (5 mg · kg-1 · h-1) significantly attenuates LPS-induced pulmonary microcirculatory disturbance, including the increase in leukocyte adhesion and albumin leakage. In addition, LPS increases pulmonary tissue wet-to-dry weight ratio and tumor necrosis factor [alpha] and interleukin 8 levels in plasma and bronchoalveolar lavage fluid enhances the expression of E-selectin, intercellular adhesion molecule 1, myeloperoxidase, MMP-2, and MMP-9, whereas it decreases the expression of AQP-1 and AQP-5 in pulmonary tissue, all of which are attenuated by SalB pretreatment[1]. SalB administration (10 mg/kg) significantly ameliorate the Aβ25-35 peptide-induced memory impairment in the passive avoidance task (P<0.05). SalB treatment also reduced the number of activated microglia and astrocytes that are observed during the inflammatory reaction after the administration of the Aβ25-35 peptide. Moreover, SalB markedly reduce inducible nitric oxide synthase and cyclooxygenase-2 expression levels and thiobarbituric acid reactive substances, which are increased by the administration of the Aβ25-35 peptide. Furthermore, SalB administration significantly rescue the Aβ25-35 peptide-induced decrease of choline acetyltransferase and brain-derived neurotrophic factor protein levels
参考文献: 1. Lee YW, et al.Neuroprotective effects of salvianolic acid B on an Aβ25-35 peptide-induced mouse model of Alzheimer's disease. Eur J Pharmacol. 2013 Mar 15;704(1-3):70-7. 2. Liu P, et al. Effect of salvianolic acid B on collagen production and mitogen-activated protein kinase activity in rat hepatic stellate cells. Acta Pharmacol Sin. 2002 Aug;23(8):733-8. 3. Lin, Fang, et al. Salvianolic acid B protects from pulmonary microcirculation disturbance induced by lipopolysaccharide in rat. Shock. 2013 Mar;39(3):317-25. 4. Man Xu, et al. Analysis on the Stability of Total Phenolic Acids and Salvianolic Acid B from Salvia miltiorrhiza by HPLC and HPLC-MSn. Natural Product Communications. 2008 Vol. 3, No. 5, 669-676.
溶解性: H2O  :  50  mg/mL  (69.58  mM;  ultrasonic  and  adjust  pH  to  3  with  HCl)    DMSO  :  25  mg/mL  (34.79  mM;  Need  ultrasonic)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 1.392 ml 6.958 ml 13.916 ml
5 mM 0.278 ml 1.392 ml 2.783 ml
10 mM 0.139 ml 0.696 ml 1.392 ml
50 mM 0.028 ml 0.139 ml 0.278 ml
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