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• 产品描述： BRD73954 is a potent HDAC inhibitor and selectively inhibiting both HDAC6 and HDAC8 with IC50 values of 0.0036, 0.12, 9, 12, 23 µM for HDAC6, HDAC8, HDAC2, HDAC1 and HDAC3, respectively. BRD73954 decreases the levels of HDAC6, associated with upregulation of Ac-Tubulin

• 靶点： HDAC6:0.036 μM (IC50);HDAC8:0.12 μM (IC50);HDAC2:9 μM (IC50);HDAC

• 体外研究：
  BRD73954 (10 µM; 48 h; HeLa cells) inhibits HDAC6 activity via upregulation of Ac-Tubulin. Western Blot Analysis Cell Line: HeLa cells Concentration: 10 µM Incubation Time: 48 hours Result: Increased inα-tubulin acetylation, no change in the acetylation state of H3 was observed.

• 参考文献：
  1. Olson DE, et, al. Discovery of the first histone deacetylase 6/8 dual inhibitors. J Med Chem. 2013 Jun 13;56(11):4816-20.

• 溶解性： soluble  in  DMSO

• 保存条件： -20℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	3.517 ml	17.586 ml	35.173 ml
  5 mM	0.703 ml	3.517 ml	7.035 ml
  10 mM	0.352 ml	1.759 ml	3.517 ml
  50 mM	0.07 ml	0.352 ml	0.703 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *