| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
| S81336-1mg | 98% | ￥160.00 | 10 | - | - | - |
|
| S81336-2mg | 98% | ￥300.00 | 10 | - | - | - |
|
| S81336-5mg | 98% | ￥490.00 | 6 | - | - | - |
|
| S81336-10mg | 98% | ￥600.00 | 6 | - | - | - |
|
| S81336-25mg | 98% | ￥1000.00 | 5 | - | - | - |
|
| S81336-50mg | 98% | ￥1700.00 | 货期：2-3天 | - | - | - |
|
| S81336-100mg | 98% | ￥2700.00 | 货期：2-3天 | - | - | - |
|
BRD73954 is a potent HDAC inhibitor and selectively inhibiting both HDAC6 and HDAC8 with IC50 values of 0.0036, 0.12, 9, 12, 23 µM for HDAC6, HDAC8, HDAC2, HDAC1 and HDAC3, respectively. BRD73954 decreases the levels of HDAC6, associated with upregulation of Ac-Tubulin
| 产品描述： | BRD73954 is a potent HDAC inhibitor and selectively inhibiting both HDAC6 and HDAC8 with IC50 values of 0.0036, 0.12, 9, 12, 23 µM for HDAC6, HDAC8, HDAC2, HDAC1 and HDAC3, respectively. BRD73954 decreases the levels of HDAC6, associated with upregulation of Ac-Tubulin | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | HDAC6:0.036 μM (IC50);HDAC8:0.12 μM (IC50);HDAC2:9 μM (IC50);HDAC | ||||||||||||||||||||
| 体外研究： | BRD73954 (10 µM; 48 h; HeLa cells) inhibits HDAC6 activity via upregulation of Ac-Tubulin. Western Blot Analysis Cell Line: HeLa cells Concentration: 10 µM Incubation Time: 48 hours Result: Increased inα-tubulin acetylation, no change in the acetylation state of H3 was observed. | ||||||||||||||||||||
| 参考文献： | 1. Olson DE, et, al. Discovery of the first histone deacetylase 6/8 dual inhibitors. J Med Chem. 2013 Jun 13;56(11):4816-20. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
|
||||||||||||||||||||
| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
沪公网安备 31011702002021号
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京