SMER28 99%

SMER28

源叶(MedMol)
S81453
307538-42-7
C11H10BrN3
264.1212
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S81453-2mg 99% ¥170.00元 4 - - -
源叶(MedMol) S81453-5mg 99% ¥305.00元 6 - - -
源叶(MedMol) S81453-10mg 99% ¥374.00元 2 - - -
源叶(MedMol) S81453-25mg 99% ¥630.00元 6 - - -
源叶(MedMol) S81453-50mg 99% ¥1100.00元 预计交期:2-3天 - - -
源叶(MedMol) S81453-100mg 99% ¥1840.00元 预计交期:2-3天 - - -
源叶(MedMol) S81453-250mg 99% ¥3500.00元 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

SMER28 is a positive regulator of autophagy acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide
产品描述: SMER28 is a positive regulator of autophagy acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide
靶点: Autophagy
体外研究: SMER28 (5-200 μM; 24 hours) shows a dose dependent decline of cell viability. Cell Viability Assay Cell Line: MMS1 cells Concentration: 5, 25, 50, 75, 100, 150, 200 μM Incubation Time: 24 hours Result: Showed a dose dependent decline of cell viability.
体内研究: SMER28 (15-65 mg/kg; i.h.; daily, two days before irradiation and during the three days of irradiation) significantly protects against post-irradiation weight loss and enhances survival of mice at 65 mg/kg. Animal Model: 14 to 16 weeks male mice (Balb/c) Dosage: 15, 65 mg/kg Administration: Subcutaneous injection; two days before irradiation and during the three days of irradiation (total 5 days) Result: Significantly protected against post-irradiation weight loss and enhanced survival of mice at 65 mg/kg.
参考文献: 1. Renna M et al. Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J Biol Chem. 2010 Apr 9;285(15):11061-7. 2. Nekova TS, et al. Small molecule enhancers of rapamycin induce apoptosis in myeloma cells via GSK3A/Bpreferentially within a protective bone marrow microenvironment. Br J Haematol. 2014 Oct;167(2):272-4. 3. Shen D et al. Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies. Cell Biochem Biophys. 2011 Jul;60(3):173-85. 4. Koukourakis MI, et al. SMER28 is a mTOR-independent small molecule enhancer of autophagy that protects mouse bone marrow and liver against radiotherapy. Invest New Drugs. 2018 Oct;36(5):773-781. 5. Tian Y et al. A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. FASEB J. 2011 Jun;25(6):1934-42.
溶解性: soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 3.786 ml 18.931 ml 37.861 ml
5 mM 0.757 ml 3.786 ml 7.572 ml
10 mM 0.379 ml 1.893 ml 3.786 ml
50 mM 0.076 ml 0.379 ml 0.757 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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