| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S81562-1mg |
99.1% | ￥168.00 | >10 | - | - | - |
|
S81562-2mg |
99.1% | ￥296.00 | >10 | - | - | - |
|
S81562-5mg |
99.1% | ￥480.00 | >10 | - | - | - |
|
S81562-10mg |
99.1% | ￥760.00 | >10 | - | - | - |
|
S81562-25mg |
99.1% | ￥1280.00 | >10 | - | - | - |
|
S81562-50mg |
99.1% | ￥1920.00 | >10 | - | - | - |
|
S81562-100mg |
99.1% | ￥2880.00 | >10 | - | - | - |
|
Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells. Enzalutamide is an autophagy activator
| 产品描述： | Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells. Enzalutamide is an autophagy activator | ||||||||||||||||||||
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| 靶点： | IC50: 36 nM (androgen-receptor, in LNCaP cells);AndrogenReceptor; Autophagy | ||||||||||||||||||||
| 体内研究： | Enzalutamide (MDV3100) induces great tumor regression in castrate male mice bearing LNCaP/AR xenografts at a dose of 10 mg/kg. Enzalutamide shows dose-independent pharmacokinetics at intravenous and oral doses of 0.5-5 mg/kg. | ||||||||||||||||||||
| 参考文献： | 1. Tran C, et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science, 2009, 324 (5928), 787-790. 2. Scher HI, et al. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study. Lancet, 2010, 375(9724), 1437-1446. 3. Guerrero J, et al. Enzalutamide, an androgen receptor signaling inhibitor, induces tumor regression in a mouse model of castration-resistant prostate cancer. Prostate. 2013 Sep;73(12):1291-305. 4. Kim TH, et al. Pharmacokinetics of enzalutamide, an anti-prostate cancer drug, in rats. Arch Pharm Res. 2015 Nov;38(11):2076-82. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 50 mg/mL (107.66 mM) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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