Lys01 (trihydrochloride)

    
≥98%

Lys01 (trihydrochloride)

源叶(MedMol)
S83085 一键复制产品信息
1391426-24-6
C23H26Cl5N5
549.751
货号 规格 价格 上海 北京 武汉 南京 购买数量
S83085-1mg ≥98% ¥206.00 5 - - -
S83085-5mg ≥98% ¥643.00 7 - - -
S83085-10mg ≥98% ¥975.00 6 - - -
S83085-25mg ≥98% ¥1044.00 6 - - -
S83085-50mg ≥98% ¥1540.00 5 - - -
S83085-100mg ≥98% ¥2060.00 4 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Lys05 (Lys01 trihydrochloride) is a novel lysosomal autophagy inhibitor with IC50 values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay.

产品描述: Lys05 (Lys01 trihydrochloride) is a novel lysosomal autophagy inhibitor with IC50 values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay.
靶点: IC50: 3.6 μM (1205Lu), 3.8 μM (c8161), 6 μM (LN229), 7.9 μM (HT-29);lysosomalautophagy; Autophagy
体外研究: Lys01, is a 10-fold more potent autophagy inhibitor than HCQ. Compared with HCQ, Lys05, a water-soluble salt of Lys01, more potently accumulates within and deacidifies the lysosome. Lys01 and Lys05 produce equivalent dose-dependent increases in the LC3II/LC3I ratio, accumulation of the autophagy cargo protein p62, and identical IC50 values in the MTT assay
体内研究: With this high-dose, short-term treatment, no mice die, but after 2 d of dosing, mice treated with Lys05 76 mg/kg i.p. are observed to have arched backs and lethargy. Morphologically, EM show that cells with intact nuclear and cytoplasmic membranes contain large AVs in Lys05-treated tumors. Tumor growth is significantly impaired in Lys05-treated tumors compared with controls. Lys05 treatment results in a 53% reduction in the average daily tumor growth rate compared with vehicle-treated controls. A significant three- and six-fold accumulation of AV is observed at the end of 14 d of treatment in HCQ- and Lys05-treated tumors, respectively, compared with control-treated tumors
参考文献: 1. McAfee Q, et al. Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8253-8.
溶解性: Soluble  in  DMSO、H2O
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 1.819 ml 9.095 ml 18.19 ml
5 mM 0.364 ml 1.819 ml 3.638 ml
10 mM 0.182 ml 0.91 ml 1.819 ml
50 mM 0.036 ml 0.182 ml 0.364 ml
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参考文献

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