TA-02

    
98%

TA-02

MedMol
S83990 一键复制产品信息
1784751-19-4
C20H13F2N3
333.3341
货号 规格 价格 上海 北京 武汉 南京 购买数量
S83990-1mg 98% ¥130.00 5 - - -
S83990-2mg 98% ¥200.00 5 - - -
S83990-5mg 98% ¥340.00 7 - - -
S83990-10mg 98% ¥540.00 4 - - -
S83990-25mg 98% ¥1090.00 4 - - -
S83990-50mg 98% ¥1630.00 货期:2-3天 - - -
S83990-100mg 98% ¥2470.00 货期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

TA-02, an analog of SB 203580 (HY-10256), is a p38 MAPK inhibitor with an IC50 of 20 nM. TA-02 especially inhibits TGFBR-2. TA-02 exhibits similar cardiogenic properties as SB 203580 and SB 202190 (HY-10295

产品描述: TA-02, an analog of SB 203580 (HY-10256), is a p38 MAPK inhibitor with an IC50 of 20 nM. TA-02 especially inhibits TGFBR-2. TA-02 exhibits similar cardiogenic properties as SB 203580 and SB 202190 (HY-10295
靶点: p38 MAPK;Autophagy;p38MAPK; Autophagy
体外研究: TA-02 (5 μM) inhibits the phosphorylation of proteins downstream of p38α MAPK such as MAPKAPK2 and HSP27 during cardiogenesis. TA-02 at 5 μM concentration induces cardiogenesis, but also increases ATF-2 phosphorylation and MEF2C õexpression in contrast to what would be expected with a mechanism dependent on p38α MAPK inhibition. TA-02 induces T/Brachyury whereas SB203580 addition increased MESP1 and T/Brachyury transcripts. TA-02 significantly induces high NKX2-5 expression when applied between days 0-8. TA-02 is found to inhibit multiple targets with similar potency to p38α MAPK, such as p38α, p38β, JNK3, JNK2, CIT, CK1ε, DMPK2, JNK1, DDR1 CK1δ, MEK5, and ERBB2. TA-02 and SB203580 reduce the nuclear TCF/LEF-1 driven transcription of luciferase similar to DKK-1.TA-02 (5 nM-5 μM) inhibits p38 and increases the anti-inflammation effects of BDNF on inflammation in vitro. Western Blot Analysis Cell Line: The nerve cell line AGE1.HN. Concentration: 5 nM-5 μM. Incubation Time: 44 h (100 ng/ml LPS for 4 h at 37°C). Result: Suppressed p-38 protein expression, reduced IL-1β, IL-6, IL-18 and TNF-α levels and inhibited iNOS and COX-2 levels in an in vitro model of SCI by BDNF overexpression, compared with the BDNF overexpression group.
参考文献: 1. Laco F, et al. Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling. J Mol Cell Cardiol. 2015 Mar;80:56-70. 2. Jiedong Liang, et al. The activation of BDNF reduced inflammation in a spinal cord injury model by TrkB/p38 MAPK signaling. Exp Ther Med. 2019 Mar;17(3):1688-1696.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 3 ml 15 ml 30 ml
5 mM 0.6 ml 3 ml 6 ml
10 mM 0.3 ml 1.5 ml 3 ml
50 mM 0.06 ml 0.3 ml 0.6 ml
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