CL 82198 98%

CL 82198

源叶(MedMol)
S84860
307002-71-7
C17H33N2O3
302.37
N-[4-(4-MORPHOLINYL)BUTYL]-2-BENZOFURANCARBOXAMIDE ;N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide;N-(4-morpholin-4-ylbutyl)-1-benzofuran-2-carboxamide,
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S84860-5mg 98% ¥140.00元 9 - - -
源叶(MedMol) S84860-10mg 98% ¥240.00元 8 - - -
源叶(MedMol) S84860-25mg 98% ¥500.00元 7 - - -
源叶(MedMol) S84860-50mg 98% ¥850.00元 3 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs. CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression
产品描述: CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs. CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression
靶点: MMP
体内研究: CL82198 (1-10 mg/kg; i.p.; every other day for 12 weeks) prevents and decelerates MLI-induced osteoarthritis progression
参考文献: 1. Rath T et al. Matrix metalloproteinase-13 is regulated by toll-like receptor-9 in colorectal cancer cells and mediates cellular migration. Oncol Lett. 2011 May;2(3):483-488. 2. George J, et al. MMP-13 deletion decreases profibrogenic molecules and attenuates N-nitrosodimethylamine-induced liver injury and fibrosis in mice. J Cell Mol Med. 2017 Dec;21(12):3821-3835. 3. Wohlauer M et al. Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13. Crit Care Med. 2012 Sep;40(9):2647-53. 4. Wang M,et al. MMP13 is a critical target gene during the progression of osteoarthritis. Arthritis Res Ther. 2013 Jan 8;15(1):R5.
溶解性: Soluble  in  DMSO
保存条件: 2-8℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 3.307 ml 16.536 ml 33.072 ml
5 mM 0.661 ml 3.307 ml 6.614 ml
10 mM 0.331 ml 1.654 ml 3.307 ml
50 mM 0.066 ml 0.331 ml 0.661 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

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