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S87130

MSX-122

源叶(MedMol) 98%
  • 英文名:
  • MSX-122
  • 别名:
  • CAS号:
  • 897657-95-3
  • 分子式:
  • C16H16N6
  • 分子量:
  • 292.3384
  • 核磁/质谱:
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源叶(MedMol) S87130-5mg 98% ¥425.00元 5 - - - EA 加入购物车
源叶(MedMol) S87130-10mg 98% ¥663.00元 4 - - - EA 加入购物车
源叶(MedMol) S87130-25mg 98% ¥1275.00元 5 - - - EA 加入购物车
源叶(MedMol) S87130-100mg 98% ¥3500.00元 3 - - - EA 加入购物车
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参考文献

质检证书(COA)

摩尔浓度计算器

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  • 提示:详情请下载说明书。
  • 产品描述: MSX-122 (Q-122)是一种新型的CXCR4部分拮抗剂,IC50约为10 nM
  • 靶点: CXCR4:~10 nM;CXCR
  • 体外研究:
    MSX-122 is also incapable of blocking the binding of 125I-labeled CXCL12 to CXCR4. MSX-122 appears to be insufficiently large to block all binding sites between CXCR4 and CXCL12. MSX-122 blocks certain CXCR4 functions via binding to the CXCL12-binding site and interfering with CXCR4/CXCL12-mediated signaling. MSX-122 can intervene in the Gαi-signaling pathway (cAMP modulation), but not the Gq-pathway (calcium flux)
  • 体内研究:
    MSX-122 blocks bleomycin-induced lung fibrosis involving chemotaxis and homing of CXCR4-positive mesenchymal progenitor cells into the lungs. MSX-122 exhibits anti-inflammatory activity in a carrageenan-induced paw edema model. MSX-122 blocks lung metastasis of breast cancer and SCCHN, and liver metastasis of uveal melanoma in vivo
  • 细胞实验: Cell lines: MDA-MB-231 cells Concentrations: 1, 10, 100, and 1000 nM Incubation Time: 15 mins Method: For binding affinity assay, MDA-MB-231 cells cultured in an 8-well slide chamber are preincubated with MSX-122 at 1, 10, 100, and 1000 nM. Then the cells are fixed with 4% formaldehyde and incubated with 50 nM biotinylated TN14003, and followed by Rhodamine staining.
  • 动物实验: Animal Models: Male C57BL/6 mice (age 5–6 weeks) Dosages: 10 mg/kg Administration: i.p. injection
  • 参考文献:
    1. Liang Z, et al. Development of a unique small molecule modulator of CXCR4. PLoS One. 2012, 7(4):e34038.
  • 溶解性: Soluble  in  DMSO
  • 保存条件: -20℃
  • 配置溶液浓度参考:
    1mg 5mg 10mg
    1 mM 3.421 ml 17.103 ml 34.207 ml
    5 mM 0.684 ml 3.421 ml 6.841 ml
    10 mM 0.342 ml 1.71 ml 3.421 ml
    50 mM 0.068 ml 0.342 ml 0.684 ml
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)


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