根皮素

    
分析标准品,HPLC≥98%

Phloretin

源叶
B20450 一键复制产品信息
60-82-2
C15H14O5
274.27
MFCD00002288
2',4',6'-三羟基-3-(4-羟基苯基)苯丙酮;3-(4-羟苯基)-1-(2,4,6-三羟基苯基)-1-丙酮
货号 规格 价格 上海 北京 武汉 南京 购买数量
B20450-20mg 分析标准品,HPLC≥98% ¥350.00 >10 2 - 5
B20450-100mg 分析标准品,HPLC≥98% ¥1200.00 >10 - - -
产品介绍 参考文献(53篇) 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

根皮素  Phloretin (NSC 407292; RJC 02792) 是一种从苹果中提取的黄酮类化合物,具有抗炎活性。Phloridzin 是一种特异性、竞争性和口服活性的钠/葡萄糖协同转运蛋白 (sodium/glucose cotransporters) 抑制剂,在肠道 (SGLT1) 和肾脏 (SGLT2)。Phloretin 抑制 Yeast-made GLUT1 以及人类红细胞 GLUT1 的 IC50 值分别为 49 μM 和 61 μM。Phloretin 具有潜力用于类风湿性关节炎 (RA) 和过敏性气道炎症的相关研究。

熔点: 260-262°C
沸点: 534.4 °C at 760 mmHg
外观: 淡红色粉末状
溶解性: DMSO  :  50  mg/mL  (182.30  mM;  Need  ultrasonic)

H2O  :  0.1  mg/mL  (0.36  mM;  Need  ultrasonic)
敏感性: 对热和光敏感
储存条件: -20℃
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献(53篇)

48. [IF=5.1] Qi Gu et al."The natural dihydrochalcone phloretin reduces lipid accumulation via downregulation of IIS and sbp-1/SREBP pathways in HepG2 cells and Caenorhabditis elegans."Food & Function.2025 Apr;: 47. [IF=5.6] Yifan Liu et al."Preparation of hapten and monoclonal antibody of hesperetin and establishment of enzyme-linked immunosorbent assay."TALANTA.2025 Jan;281:126912 46. [IF=10.1] Hongfa Lv et al."Phloretin Targets Polyphosphate Kinase 1 to Attenuate Acinetobacter baumannii Virulence and Persistence In Vitro and In Vivo."Engineering.2024 Sep;: 45. [IF=8.5] Wangsheng Sun et al."Effect of sequential fermentation with indigenous non-Saccharomyces cerevisiae combinations and Saccharomyces cerevisiae on the chemical composition and aroma compounds evolution of kiwifruit wine."FOOD CHEMISTRY.2024 Dec;460:140758 44. [IF=3.7] Zhongyu Lu et al."Pharmaceutical Properties of the Phloretin–4,4′-Bipyridine Cocrystal: Structure Analysis, Drug Release Profile, and Antioxidant Activity Research."ACS Omega.2024;XXXX(XXX):XXX-XXX 43. [IF=7.4] Yu Zhang et al."Phloretin Prolongs Lifespan of Caenorhabditis elegans via Inhibition of NDUFS1 and NDUFS6 at Mitochondrial Complex Ⅰ."FREE RADICAL BIOLOGY AND MEDICINE".2024 May;: 42. [IF=5.6] Wenlong Zhang et al."Exogenous Melatonin Enhances Dihydrochalcone Accumulation in Lithocarpus litseifolius Leaves via Regulating Hormonal Crosstalk and Transcriptional Profiling."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES".2024 Jan;25(9):4592 41. [IF=5.6] Han Yu et al."Functional Identification of HhUGT74AG11—A Key Glycosyltransferase Involved in Biosynthesis of Oleanane-Type Saponins in Hedera helix."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES".2024 Jan;25(7):4067 40. [IF=5.2] Pengfei Bi et al."Characterization of the effect of non-Saccharomyces cerevisiaes on the non-volatile constituents and volatile profiles of low-alcoholic pomegranate beverages."Food Bioscience".2024 Jun;59:103870 39. [IF=5.6] Wang Mengting et al."Chinese bayberry (Myrica rubra Sieb. et Zucc.) leaves proanthocyanidins inhibit intestinal glucose transport in human Caco-2 cells."Frontiers in Pharmacology".2024 Feb;15: 38. [IF=5.6] Yan Duan et al."UPLC-Q–TOF–MS, network analysis, and molecular docking to investigate the effect and active ingredients of tea-seed oil against bacterial pathogens."Frontiers in Pharmacology.10.3389/fphar.2023.1225515 37. [IF=6.1] Jie Li et al."Phloretin alleviates palmitic acid-induced oxidative stress in HUVEC cells by suppressing the expression of LncBAG6-AS."Food & Function.10.1039/D3FO03523A 36. [IF=7.9] Qingqing Ruan et al."Phloretin-induced STAT3 inhibition suppresses pancreatic cancer growth and progression via enhancing Nrf2 activity."PHYTOMEDICINE.2023 Sep;118:154990 35. [IF=1.7] Zhouyi Zhang et al."Revealing the differences in phenolics in different parts of Taraxacum mongolicum using UPLC-MS/MS."Phytochemistry Letters.2023 Aug;56:13 34. [IF=6] Xiaoyue Yang et al."Effect of plant polyphenols with different m-hydroxy and o-hydroxy groups on the inhibition of heterocyclic amines formation in roasted meat."FOOD CONTROL.2023 Jun;:109960 33. [IF=1.967] ke Zunli et al."Physicochemical characteristics, polyphenols and antioxidant activities of Dimocarpus longan grown in different geographical locations."ANALYTICAL SCIENCES.2023 Apr;:1-8 32. [IF=4.036] Zhongyu Lu et al."Cocrystal of phloretin with isoniazid: preparation, characterization, and evaluation."RSC Advances.2023 Apr;13(16):10914-10922 31. [IF=4.927] Wengang Zhang et al."Polyphenol Profile and In Vitro Antioxidant and Enzyme Inhibitory Activities of Different Solvent Extracts of Highland Barley Bran."MOLECULES.2023 Jan;28(4):1665 30. [IF=6.317] Qingqing Ma et al."Thinned young apple polyphenol may prevent neuronal apoptosis by up-regulating 5-hydroxymethylcytosine in cerebral cortex of high-fat diet-induced diabetic mice."Food & Function.2023 Feb;: 29. [IF=5.581] Li, Yuanyuan et al."Simultaneous Extraction of Flavonoid Glycosides and Flavonoid Aglycones from Discarded Apple Branches by Enzyme-assisted Micelle-mediated Extraction with Cloud Point Enrichment Method."Food and Bioprocess Technology.2022 Dec;:1-13 28. [IF=7.31] Dan Song et al."Protective Effect of Phloretin against Hydrogen Peroxide-Induced Oxidative Damage by Enhancing Autophagic Flux in DF-1 Cells."Oxidative Medicine and Cellular Longevity.2022 Dec 30;2022:8359118 27. [IF=5.561] Xueshan Yang et al."Effect of Deacidification Treatment on the Flavor Quality of Zaosu Pear–Kiwifruit Wine."Foods.2022 Jan;11(14):2007 26. [IF=6.208] Yan Chen et al."Characterization of the Key Bibenzyl Synthase in Dendrobium sinense."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2022 Jan;23(12):6780 25. [IF=6.576] Junkun Pan et al."Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure–Activity Relationship, Kinetics and Interaction Mechanism."Frontiers in Nutrition. 2022; 9: 892426 24. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155 23. [IF=2.391] Tan Si et al."Effects of three drying methods on polyphenol composition and antioxidant activities of Litchi chinensis Sonn.."Food Sci Biotechnol. 2020 Mar;29(3):351-358 22. [IF=4.171] Lin Han et al."Activation of AMPK/Sirt3 pathway by phloretin reduces mitochondrial ROS in vascular endothelium by increasing the activity of MnSOD via deacetylation."Food Funct. 2020 Apr;11(4):3073-3083 21. [IF=4.24] Mengzhen Han et al."Effect of mixed Lactobacillus on the physicochemical properties of cloudy apple juice with the addition of polyphenols-concentrated solution."Food Biosci. 2021 Jun;41:101049 20. [IF=4.952] Si Tan et al."The effects of drying methods on chemical profiles and antioxidant activities of two cultivars of Psidium guajava fruits."Lwt Food Sci Technol. 2020 Jan;118:108723 19. [IF=5.537] Tiantian Tang et al."A difference of enzymatic browning unrelated to PPO from physiology, targeted metabolomics and gene expression analysis in Fuji apples."Postharvest Biol Tec. 2020 Dec;170:111323 18. [IF=5.64] Zhang Yuxiang et al."Structure-Dependent Inhibition of Stenotrophomonas maltophilia by Polyphenol and Its Impact on Cell Membrane."Front Microbiol. 2019 Nov;0:2646 17. [IF=5.81] Mu Jianfei et al."Determination of Polyphenols in Ilex kudingcha and Insect Tea (Leaves Altered by Animals) by Ultra-high-performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry (UHPLC-QqQ-MS) and Comparison of Their Anti-Aging Effects."Fro 16. [IF=7.514] Hongcai Li et al."Study on the nutritional characteristics and antioxidant activity of dealcoholized sequentially fermented apple juice with Saccharomyces cerevisiae and Lactobacillus plantarum fermentation."Food Chem. 2021 Nov;363:130351 15. [IF=7.514] Jing Zhao et al."A sensitive and practical ELISA for analyzing naringenin in pummelo and herb samples."Food Chem. 2021 Nov;362:130223 14. [IF=7.514] Pei Pu et al."Six flavonoids inhibit the antigenicity of β-lactoglobulin by noncovalent interactions: A spectroscopic and molecular docking study."Food Chem. 2021 Mar;339:128106 13. [IF=3] Xing-Yan LIU et al."Identification of active compound combination contributing to anti-inflammatory activity of Xiao-Cheng-Qi Decoction via human intestinal bacterial metabolism."Chin J Nat Medicines. 2018 Jul;16:513 12. [IF=3.571] Qing Yang et al."Activation of Nrf2 by Phloretin Attenuates Palmitic Acid-Induced Endothelial Cell Oxidative Stress via AMPK-Dependent Signaling."J Agr Food Chem. 2019;67(1):120–131 11. [IF=4.729] Kun Zhou et al."Genome-wide identification of glycosyltransferases converting phloretin to phloridzin in Malus species."Plant Sci. 2017 Dec;265:131 10. [IF=5.279] Suyun Lin et al."Dietary Flavonoids as Xanthine Oxidase Inhibitors: Structure–Affinity and Structure–Activity Relationships."J Agr Food Chem. 2015;63(35):7784–7794 9. [IF=6.529] Xing-Yan Liu et al."The activity of Hou-Po-Da-Huang-Tang is improved through intestinal bacterial metabolism and Hou-Po-Da-Huang-Tang selectively stimulate the growth of intestinal bacteria associated with health."Biomed Pharmacother. 2017 Oct;94:794 8. [IF=6.953] Lin Han et al."Inhibitory effect of phloretin on α-glucosidase: Kinetics, interaction mechanism and molecular docking."Int J Biol Macromol. 2017 Feb;95:520 7. Tiantian Tang, Xinfang Xie, Xue Ren, Wenjun Wang, Xuanming Tang, Jie Zhang, Zhidong Wang, A difference of enzymatic browning unrelated to PPO from physiology, targeted metabolomics and gene expression analysis in Fuji apples, Postharvest Biology and Techno 6. Pei Pu, Xin Zheng, Linna Jiao, Lang Chen, Han Yang, Yonghong Zhang, Guizhao Liang, Six flavonoids inhibit the antigenicity of β-lactoglobulin by noncovalent interactions: A spectroscopic and molecular docking study, Food Chemistry, Volume 339, 2021, 128106 5. Xing-Yan, L. I. U., et al. "Identification of active compound combination contributing to anti-inflammatory activity of Xiao-Cheng-Qi Decoction via human intestinal bacterial metabolism." Chinese journal of natural medicines 16.7 (2018): 513-524.https://do 4. Lin, Suyun, et al. "Dietary flavonoids as xanthine oxidase inhibitors: Structure–affinity and structure–activity relationships." Journal of agricultural and food chemistry 63.35 (2015): 7784-7794. 3. 郑妍 张春岭 刘慧 等. UPLC法测定猕猴桃果汁中的酚类物质含量[J]. 果树学报 2018 035(008):1006-1015. 2. 冉峥, 郭艳丽, 王丽凤,等. 黄诺马苷在MDCK单层细胞模型上的转运机制分析[J]. 中国实验方剂学杂志, 2019(15):155-160. 1. 张国文, 宋欣, 曾霓. 根皮素对酪氨酸酶活性与构象的影响[J]. 南昌大学学报:理科版, 2018(6):557-562.

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