CCG-1423 99%

CCG-1423

源叶(MedMol)
S80589
285986-88-1
C18H13ClF6N2O3
454.7508392
N-({1-[(4-氯苯基)氨基]-1-氧代-2-丙基}氧基)-3,5-二(三氟甲基)苯甲酰胺;N-(2-(4-Chloroanilino)-1-Methyl-2-oxoethoxy)-3,5-bis(trifluoroMethyl)benzaMide;N-(1-(4-chlorophenylaMino)-1-oxopropan-2-yloxy)-3,5-bis(trifluor
品牌 货号 产品规格 价格(RMB) 库存(上海) 北京 武汉 南京 购买数量
源叶(MedMol) S80589-5mg 99% ¥120.00元 10 - - -
源叶(MedMol) S80589-10mg 99% ¥200.00元 10 - - -
源叶(MedMol) S80589-25mg 99% ¥350.00元 8 - - -
源叶(MedMol) S80589-50mg 99% ¥520.00元 3 - - -
源叶(MedMol) S80589-100mg 99% ¥1000.00元 预计交期:2-3天 - - -
源叶(MedMol) S80589-200mg 99% ¥1900.00元 预计交期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

CCG-1423 is an inhibitor of Rho/MRTF/SRF pathway. CCG-1423 shows activities in several cancer cells. CCG-1423 is a promising lead compound for the development of novel pharmacologic tools, and it can be used for the research of cancer and diabetes
产品描述: CCG-1423 is an inhibitor of Rho/MRTF/SRF pathway. CCG-1423 shows activities in several cancer cells. CCG-1423 is a promising lead compound for the development of novel pharmacologic tools, and it can be used for the research of cancer and diabetes
靶点: IC50: 1.5 µM (Rho-pathway selective serum response element-luciferase reporter);LRRK2;Rho;Ras
体内研究: CCG-1423 (0.15 mg/kg; i.p. once daily for two weeks) affects glucose tolerance and insulin levels in HFD-fed mice
参考文献: 1. Evelyn CR, et al. Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423. Bioorg Med Chem Lett. 2010 Jan 15;20(2):665-72. 2. Jin W, et al. Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistance. J Clin Invest. 2011 Mar;121(3):918-29. 3. Evelyn CR, et al. CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling. Mol Cancer Ther. 2007 Aug;6(8):2249-60.
溶解性: DMSO  :  100  mg/mL  (219.90  mM;  ultrasonic  and  warming  and  heat  to  60°C)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.199 ml 10.995 ml 21.99 ml
5 mM 0.44 ml 2.199 ml 4.398 ml
10 mM 0.22 ml 1.1 ml 2.199 ml
50 mM 0.044 ml 0.22 ml 0.44 ml
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参考文献

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摩尔浓度计算器

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