产品描述: | CCG-1423 is an inhibitor of Rho/MRTF/SRF pathway. CCG-1423 shows activities in several cancer cells. CCG-1423 is a promising lead compound for the development of novel pharmacologic tools, and it can be used for the research of cancer and diabetes |
靶点: |
IC50: 1.5 µM (Rho-pathway selective serum response element-luciferase reporter);LRRK2;Rho;Ras |
体内研究: |
CCG-1423 (0.15 mg/kg; i.p. once daily for two weeks) affects glucose tolerance and insulin levels in HFD-fed mice |
参考文献: |
1. Evelyn CR, et al. Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423. Bioorg Med Chem Lett. 2010 Jan 15;20(2):665-72. 2. Jin W, et al. Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistance. J Clin Invest. 2011 Mar;121(3):918-29. 3. Evelyn CR, et al. CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling. Mol Cancer Ther. 2007 Aug;6(8):2249-60. |
溶解性: |
DMSO : 100 mg/mL (219.90 mM; ultrasonic and warming and heat to 60°C) |
保存条件: |
-20℃ |
配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
1 mM |
2.199 ml |
10.995 ml |
21.99 ml |
5 mM |
0.44 ml |
2.199 ml |
4.398 ml |
10 mM |
0.22 ml |
1.1 ml |
2.199 ml |
50 mM |
0.044 ml |
0.22 ml |
0.44 ml |
|
注意: |
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